Production of secondary metabolites using tissue culture-based biotechnological applications

II Ozyigit, I Dogan, A Hocaoglu-Ozyigit… - Frontiers in Plant …, 2023 - frontiersin.org
Plants are the sources of many bioactive secondary metabolites which are present in plant
organs including leaves, stems, roots, and flowers. Although they provide advantages to the …

Biosynthesis of monoterpenoid and sesquiterpenoid as natural flavors and fragrances

H Jiang, X Wang - Biotechnology Advances, 2023 - Elsevier
Terpenoids are a large class of plant-derived compounds, that constitute the main
components of essential oils and are widely used as natural flavors and fragrances. The …

Widespread biosynthesis of 16-carbon terpenoids in bacteria

YT Duan, A Koutsaviti, M Harizani, C Ignea… - Nature Chemical …, 2023 - nature.com
Terpenoids are the most diverse group of specialized metabolites with numerous
applications. Their biosynthesis is based on the five-carbon isoprene building block and, as …

Engineering yeast for the production of plant terpenoids using synthetic biology approaches

JA Bureau, ME Oliva, Y Dong, C Ignea - Natural product reports, 2023 - pubs.rsc.org
Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in
synthesizing these complex structures have stimulated the production of terpenoid …

[HTML][HTML] Exploring the potent anticancer activity of essential oils and their bioactive compounds: Mechanisms and prospects for future cancer therapy

F Mohamed Abdoul-Latif, A Ainane… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the leading causes of death worldwide, affecting millions of people each
year. Fortunately, the last decades have been marked by considerable advances in the field …

Synthetic biology advances towards a bio-based society in the era of artificial intelligence

A Iram, Y Dong, C Ignea - Current Opinion in Biotechnology, 2024 - Elsevier
Highlights•Artificial intelligence tools are emerging as valuable gears in synthetic
biology.•Plant-based products and technologies are key solutions for a bio-based …

Expanding the structural diversity of terpenes by synthetic biology approaches

R Chen, M Wang, JD Keasling, T Hu, X Yin - Trends in Biotechnology, 2024 - cell.com
Terpenoids display chemical and structural diversities as well as important biological
activities. Despite their extreme variability, the range of these structures is limited by the …

A roadmap to establish a comprehensive platform for sustainable manufacturing of natural products in yeast

G Naseri - Nature Communications, 2023 - nature.com
Secondary natural products (NPs) are a rich source for drug discovery. However, the low
abundance of NPs makes their extraction from nature inefficient, while chemical synthesis is …

The Scent of Change: Sustainable fragrances through industrial biotechnology

F Michailidou - ChemBioChem, 2023 - Wiley Online Library
Current environmental and safety considerations urge innovation to address the need for
sustainable high‐value chemicals that are embraced by consumers. This review discusses …

Non‐canonical Biosynthesis of the Brexane‐Type Bishomosesquiterpene Chlororaphen through Two Consecutive Methylation Steps in Pseudomonas chlororaphis …

N Magnus, SH von Reuss, F Braack… - Angewandte …, 2023 - Wiley Online Library
A non‐canonical biosynthetic pathway furnishing the first natural brexane‐type
bishomosesquiterpene (chlororaphen, C17H28) was elucidated in the γ‐proteobacterium …