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Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp
Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
Bile acids and FXR: novel targets for liver diseases
Bile acids (BAs) are evolutionally conserved molecules synthesized in the liver from
cholesterol and have been shown to be essential for lipid homeostasis. BAs regulate a …
cholesterol and have been shown to be essential for lipid homeostasis. BAs regulate a …
[HTML][HTML] Carleman estimates for semi-discrete parabolic operators and application to the controllability of semi-linear semi-discrete parabolic equations
In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …
Mechanisms and insights into drug resistance in cancer
H Zahreddine, KLB Borden - Frontiers in pharmacology, 2013 - frontiersin.org
Cancer drug resistance continues to be a major impediment in medical oncology. Clinically,
resistance can arise prior to or as a result of cancer therapy. In this review, we discuss …
resistance can arise prior to or as a result of cancer therapy. In this review, we discuss …
The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …
level. First, the interactions between curcumin and its molecular targets are addressed on …
An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins
T Hirota, Y Fujita, I Ieiri - Expert Opinion on Drug Metabolism & …, 2020 - Taylor & Francis
Introduction Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) lower
cholesterol synthesis in patients with hypercholesterolemia. Increased statin exposure is an …
cholesterol synthesis in patients with hypercholesterolemia. Increased statin exposure is an …
Multidrug resistance in cancer: role of ATP–dependent transporters
MM Gottesman, T Fojo, SE Bates - Nature reviews cancer, 2002 - nature.com
Chemotherapeutics are the most effective treatment for metastatic tumours. However, the
ability of cancer cells to become simultaneously resistant to different drugs—a trait known as …
ability of cancer cells to become simultaneously resistant to different drugs—a trait known as …
Peroxisome proliferator‐activated receptor alpha target genes
The peroxisome proliferator‐activated receptor alpha (PPARα) is a ligand‐activated
transcription factor involved in the regulation of a variety of processes, ranging from …
transcription factor involved in the regulation of a variety of processes, ranging from …
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of
proteins have a major impact on the pharmacological behavior of most of the drugs in use …
proteins have a major impact on the pharmacological behavior of most of the drugs in use …