Extensive prior research focused on somatic copy-number alterations (SCNAs) affecting
cancer genes, yet the extent to which recurrent SCNAs exert their influence through …

We describe a computational method that infers tumor purity and malignant cell ploidy
directly from analysis of somatic DNA alterations. The method, named ABSOLUTE, can …

The change in the DNA is a form of genetic variation in the human genome. In addition, the
DNA copy number change is also linked with the progression of many emerging diseases …

We present an allele-specific copy number analysis of the in vivo breast cancer genome. We
describe a unique bioinformatics approach, ASCAT (allele-specific copy number analysis of …

Purpose: Neuroblastoma is a pediatric cancer that continues to exact significant morbidity
and mortality. Recently, a number of cell-cycle proteins, particularly those within the Cyclin …

Differences between genomes can be due to single nucleotide variants, translocations,
inversions, and copy number variants (CNVs, gain or loss of DNA). The latter can range from …

Tumor samples are typically heterogeneous, containing admixture by normal, non-
cancerous cells and one or more subpopulations of cancerous cells. Whole-genome …

Neuroblastoma is a childhood cancer of the sympathetic nervous system that accounts for
approximately 10% of all paediatric oncology deaths,. To identify genetic risk factors for …

We describe a method for automatic detection of absolute segmental copy numbers and
genotype status in complex cancer genome profiles measured with single-nucleotide …

Since 1892, it has been widely assumed that somatic mutations are evolutionarily irrelevant
in animals because they cannot be inherited by offspring. However, some nonbilaterians …