Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …

Haemophagocytic lymphohistiocytosis (HLH) is an inflammatory syndrome that can occur
with cancer (malignancy-associated HLH) or with immune-activating therapies for cancer …

The role of the intestinal microbiota in coronavirus disease 2019 (COVID-19) is being
elucidated. Here, we analyzed the temporal changes in microbiota composition and the …

Abstract Interleukin-6 (IL-6) is a major cytokine that promotes anti-and pro-inflammatory
outcomes by activating the membrane IL-6 receptor (IL-6R) or the soluble IL-6 receptor (sIL …

Background To summarize modifiable factors for coronavirus disease 2019 (COVID-19)
suggested by Mendelian randomization studies. Methods In this systematic review, we …

Background SARS-CoV-2 infection is considered as a relapsing inflammatory process with a
dysregulation of IL-6 signalling. Classic IL-6 signalling is thought to represent a defence …

Pneumonia is the leading cause of hospital admission and mortality in coronavirus disease
2019 (COVID-19). We aimed to identify the cytokines responsible for lung damage and …

Background COVID-19 patients may experience “cytokine storm” when human immune
system produces excessive cytokines/chemokines. However, it remains unclear whether …