Innovations to culturing the uncultured microbial majority

WH Lewis, G Tahon, P Geesink, DZ Sousa… - Nature Reviews …, 2021 - nature.com
Despite the surge of microbial genome data, experimental testing is important to confirm
inferences about the cell biology, ecological roles and evolution of microorganisms. As the …

Adaptive genetic traits in pelagic freshwater microbes

MC Chiriac, M Haber… - Environmental …, 2023 - Wiley Online Library
Pelagic microbes have adopted distinct strategies to inhabit the pelagial of lakes and
oceans and can be broadly categorized in two groups: free‐living, specialized oligotrophs …

[HTML][HTML] Biosynthetic potential of the global ocean microbiome

L Paoli, HJ Ruscheweyh, CC Forneris, F Hubrich… - Nature, 2022 - nature.com
Natural microbial communities are phylogenetically and metabolically diverse. In addition to
underexplored organismal groups, this diversity encompasses a rich discovery potential for …

Epiphytic common core bacteria in the microbiomes of co-located green (Ulva), brown (Saccharina) and red (Grateloupia, Gelidium) macroalgae

DC Lu, FQ Wang, RI Amann, H Teeling, ZJ Du - Microbiome, 2023 - Springer
Background Macroalgal epiphytic microbial communities constitute a rich resource for novel
enzymes and compounds, but studies so far largely focused on tag-based microbial diversity …

A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity

D Wylensek, TCA Hitch, T Riedel, A Afrizal… - Nature …, 2020 - nature.com
Our knowledge about the gut microbiota of pigs is still scarce, despite the importance of
these animals for biomedical research and agriculture. Here, we present a collection of …

Planctomycetes as host-associated bacteria: a perspective that holds promise for their future isolations, by mimicking their native environmental niches in clinical …

OD Kaboré, S Godreuil, M Drancourt - Frontiers in Cellular and …, 2020 - frontiersin.org
Traditionally recognized as environmental bacteria, Planctomycetes have just been linked
recently to human pathology as opportunistic pathogens, arousing a great interest for clinical …

Functional and evolutionary significance of unknown genes from uncultivated taxa

Á Rodríguez del Río, J Giner-Lamia, CP Cantalapiedra… - Nature, 2024 - nature.com
Many of the Earth's microbes remain uncultured and understudied, limiting our
understanding of the functional and evolutionary aspects of their genetic material, which …

The confluence of big data and evolutionary genome mining for the discovery of natural products

MG Chevrette, A Gavrilidou, S Mantri… - Natural product …, 2021 - pubs.rsc.org
This review covers literature between 2003–2021 The development and application of
genome mining tools has given rise to ever-growing genetic and chemical databases and …

Antiphage small molecules produced by bacteria–beyond protein-mediated defenses

A Hardy, L Kever, J Frunzke - Trends in microbiology, 2023 - cell.com
Bacterial populations face the constant threat of viral predation exerted by bacteriophages
('phages'). In response, bacteria have evolved a wide range of defense mechanisms against …

[HTML][HTML] From ocean to medicine: Pharmaceutical applications of metabolites from marine bacteria

JD Santos, I Vitorino, F Reyes, F Vicente, OM Lage - Antibiotics, 2020 - mdpi.com
Oceans cover seventy percent of the planet's surface and besides being an immense
reservoir of biological life, they serve as vital sources for human sustenance, tourism …