Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

Significance: When a cutaneous injury occurs, the wound heals via a dynamic series of
physiological events, including coagulation, granulation tissue formation, re …

It is estimated worldwide that over 6 million people per annum experience a burn injury.
Despite advances in management and improved survival rates, the incidence of …

Although hypertrophic scars and keloids both generate excessive scar tissue, keloids are
characterized by their extensive growth beyond the borders of the original wound, which is …

Keloids are considered as benign fibroproliferative skin tumors growing beyond the site of
the original dermal injury. Although traditionally viewed as a form of skin scarring, keloids …

Skin wound healing is essential to health and survival. Consequently, high amounts of
research effort have been put into investigating the cellular and molecular components …

In 1889, Dr. Stephen Paget proposed the “seed and soil” hypothesis, which states that
cancer cells (the seeds) need the proper microenvironment (the soil) for them to grow …

The NADPH oxidase (NOX) family of enzymes produces ROS as their sole function and is
becoming recognized as key modulators of signal transduction pathways with a …

Hypertrophic scars and keloids are firm, raised, erythematous plaques or nodules that
manifest when the cicatrix fails to properly heal. They result from pathologic wound healing …

Most cutaneous wounds heal with scar formation. Ideally, an inconspicuous normotrophic
scar is formed, but an abnormal scar (hypertrophic scar or keloid) can also develop. A major …