Cancer has long been considered a genetic disease characterized by a myriad of mutations
that drive cancer progression. Recent accumulating evidence indicates that the …

Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive
oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration …

Summary N 6-Methyladenosine (m 6 A) modification and its modulators play critical roles
and show promise as therapeutic targets in human cancers, including acute myeloid …

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic
mutations and loss of tumor suppressors. Mounting evidence indicates that altered …

Background & Aims Cirrhosis results from accumulation of myofibroblasts derived from
quiescent hepatic stellate cells (Q-HSCs); it regresses when myofibroblastic HSCs are …

Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells
within different tumor types and is responsible for treatment failure. Cancer stem cells …

Cancer cells re-program their metabolic machinery to meet the requirements of malignant
transformation and progression. Glutaminase 1 (GLS1) was traditionally known as a …

How mitochondrial glutaminolysis contributes to redox homeostasis in cancer cells remains
unclear. Here we report that the mitochondrial enzyme glutamate dehydrogenase 1 (GDH1) …

Reactive oxygen species (ROS) have been implicated in tumorigenesis (tumor initiation,
tumor progression, and metastasis). Of the many cellular sources of ROS generation, the …

Abstract Cancer Stem cells (CSCs) are a unipotent cell population present within the tumour
cell mass. CSCs are known to be highly chemo-resistant, and in recent years, they have …