Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

H Cao, L Duan, Y Zhang, J Cao, K Zhang - Signal transduction and …, 2021 - nature.com
Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

Biomimetic peptide self-assembly for functional materials

A Levin, TA Hakala, L Schnaider… - Nature Reviews …, 2020 - nature.com
Natural biomolecular systems have evolved to form a rich variety of supramolecular
materials and machinery fundamental to cellular function. The assembly of these structures …

Accelerating the prediction and discovery of peptide hydrogels with human-in-the-loop

T Xu, J Wang, S Zhao, D Chen, H Zhang… - Nature …, 2023 - nature.com
The amino acid sequences of peptides determine their self-assembling properties. Accurate
prediction of peptidic hydrogel formation, however, remains a challenging task. This work …

Self-assembling peptide EAK16 and RADA16 nanofiber scaffold hydrogel

F Gelain, Z Luo, S Zhang - Chemical reviews, 2020 - ACS Publications
Short peptides are ubiquitous in nature. They are found as hormones, pheromones,
antibacterial and antifungal agents in innate immunity systems, toxins, and pesticides. But …

Enzymatic noncovalent synthesis

H He, W Tan, J Guo, M Yi, AN Shy, B Xu - Chemical reviews, 2020 - ACS Publications
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

Self‐assembled peptide‐based nanomaterials for biomedical imaging and therapy

GB Qi, YJ Gao, L Wang, H Wang - Advanced materials, 2018 - Wiley Online Library
Peptide‐based materials are one of the most important biomaterials, with diverse structures
and functionalities. Over the past few decades, a self‐assembly strategy is introduced to …

Photoresponsive biomaterials for targeted drug delivery and 4D cell culture

ER Ruskowitz, CA DeForest - Nature Reviews Materials, 2018 - nature.com
Biological signalling is regulated through a complex and tightly choreographed interplay
between cells and their extracellular matrix. The spatiotemporal control of these interactions …

Cell spheroid creation by transcytotic intercellular gelation

J Guo, F Wang, Y Huang, H He, W Tan, M Yi… - Nature …, 2023 - nature.com
Cell spheroids bridge the discontinuity between in vitro systems and in vivo animal models.
However, inducing cell spheroids by nanomaterials remains an inefficient and poorly …

Amino acids and peptide‐based supramolecular hydrogels for three‐dimensional cell culture

XQ Dou, CL Feng - Advanced Materials, 2017 - Wiley Online Library
Supramolecular hydrogels assembled from amino acids and peptide‐derived hydrogelators
have shown great potential as biomimetic three‐dimensional (3D) extracellular matrices …

Intracellular condensates of oligopeptide for targeting lysosome and addressing multiple drug resistance of cancer

J Wang, L Hu, H Zhang, Y Fang, T Wang… - Advanced …, 2022 - Wiley Online Library
Biomolecular condensates have been demonstrated as a ubiquitous phenomenon in
biological systems and play a crucial role in controlling cellular functions. However, the …