In Silico Analysis of High‐Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS‐CoV‐2 Infection

A Saih, H Baba, M Bouqdayr, H Ghazal… - BioMed research …, 2021 - Wiley Online Library
SARS‐CoV‐2 coronavirus uses for entry to human host cells a SARS‐CoV receptor of the
angiotensin‐converting enzyme (ACE2) that catalyzes the conversion of angiotensin II into …

In silico analyses of acetylcholinesterase (AChE) and its genetic variants in interaction with the anti‐Alzheimer drug Rivastigmine

GRC Pereira, LM Gonçalves… - Journal of Cellular …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Despite causing great
social and economic impact, there is currently no cure for AD. The most effective therapy to …

Computational insights into NIMA-related kinase 6: Unraveling mutational effects on structure and function

NK Panchal, S Mohanty, SE Prince - Molecular and Cellular Biochemistry, 2024 - Springer
The NEK6 (NIMA-related kinase 6) serine/threonine kinase is a pivotal player in a multitude
of cellular processes, including the regulation of the cell cycle and the response to DNA …

Computational studies on bacterial secondary metabolites against breast cancer

Z Ravnik, I Muthiah, P Dhanaraj - Journal of Biomolecular …, 2021 - Taylor & Francis
Microbes exist in the human body provide more benefits by modulating metabolic
processes, immunity, and signal transduction. However, microbial dysbiosis with harmful …

ChaperISM: improved chaperone binding prediction using position-independent scoring matrices

MBB Gutierres, CBC Bonorino, MM Rigo - Bioinformatics, 2020 - academic.oup.com
Motivation Understanding the mechanisms of client protein interaction with Hsp70
chaperones is essential to analyze the complex dynamics in the context of normal or …

Computational analysis of the potential impact of MTC complex missenses SNPs associated with male infertility

H Harmak, H Charoute, S Redouane… - BioMed Research …, 2022 - Wiley Online Library
Meiotic chromosomes endure rapid prophase movements that ease the formation of
interhomologue recombination intermediates that drive synapsis, crossing over, and …

A Simulation Analysis and Screening of Deleterious Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Sheep LEP Gene

S Girmay, HI Ahmad, QA Zahra - BioMed Research …, 2022 - Wiley Online Library
Leptin is a polypeptide hormone produced in the adipose tissue and governs many
processes in the body. Recently, polymorphisms in the LEP gene revealed a significant …

A computational study on structural and functional consequences of nsSNPs in human dopa decarboxylase

SB Kumar, A Girish, S Sutar… - Journal of …, 2024 - Taylor & Francis
Abstract The Dopa Decarboxylase (DDC) gene plays an important role in the synthesis of
biogenic amines such as dopamine, serotonin, and histamine. Non-synonymous single …

In-silico assessment of the potential impact of missense SNPs in SYNE4 and SUN1 on the LINC complex and their association with hearing loss

M Toure, S Redouane, H Charoute, A Malki, H Rouba… - Human Gene, 2024 - Elsevier
The LINC complex plays a significant role in the auditory system, as it participates in
maintaining proper positioning and survival of the nucleus within the outer hair cells. To …

Computational Analysis of Non-synonymous SNPs in ATM Kinase: Structural Insights, Functional Implications, and Inhibitor Discovery

NK Panchal, P Samdani, T Sengupta… - Molecular Biotechnology, 2024 - Springer
Ataxia telangiectasia-mutated (ATM) protein kinase, a key player in cellular integrity
regulation, is known for its role in DNA damage response. This study investigates the …