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Hepatitis B virus molecular biology and pathogenesis
As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …
Cell cycle regulation during viral infection
To replicate their genomes in cells and generate new progeny, viruses typically require
factors provided by the cells that they have infected. Subversion of the cellular machinery …
factors provided by the cells that they have infected. Subversion of the cellular machinery …
Hepatitis B virus-induced oncogenesis
Hepatocellular carcinoma (HCC) is one of the most common cancers in the world with an
annual incidence of more than 500 000 in the year 2000. Its incidence is rising in many …
annual incidence of more than 500 000 in the year 2000. Its incidence is rising in many …
The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication
Worldwide, there are over 350 million people who are chronically infected with the human
hepatitis B virus (HBV); chronic HBV infections are associated with the development of …
hepatitis B virus (HBV); chronic HBV infections are associated with the development of …
A bioinformatics investigation into molecular mechanism of Yinzhihuang granules for treating hepatitis B by network pharmacology and molecular docking verification
J Zhang, X Liu, W Zhou, G Cheng, J Wu, S Guo, S Jia… - Scientific reports, 2020 - nature.com
Yinzhihuang granules (YZHG) is a patented Chinese medicine for the treatment of hepatitis
B. This study aimed to investigate the intrinsic mechanisms of YZHG in the treatment of …
B. This study aimed to investigate the intrinsic mechanisms of YZHG in the treatment of …
Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2
S Schaedler, J Krause, K Himmelsbach… - Journal of Biological …, 2010 - jbc.org
The expression of a variety of cytoprotective genes is regulated by short cis-acting elements
in their promoters, called antioxidant response elements (AREs). A central regulator of ARE …
in their promoters, called antioxidant response elements (AREs). A central regulator of ARE …
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis
VE Gurtsevitch - Biochemistry (Moscow), 2008 - Springer
Chronic infections caused by hepatitis B virus (HBV) and/or hepatitis C virus (HCV) are the
main risk factors for the development of hepatocellular carcinoma (HCC) in humans. Both …
main risk factors for the development of hepatocellular carcinoma (HCC) in humans. Both …
Hepatitis B virus inhibits insulin receptor signaling and impairs liver regeneration via intracellular retention of the insulin receptor
SR Barthel, R Medvedev, T Heinrich… - Cellular and Molecular …, 2016 - Springer
Hepatitis B virus (HBV) causes severe liver disease but the underlying mechanisms are
incompletely understood. During chronic HBV infection, the liver is recurrently injured by …
incompletely understood. During chronic HBV infection, the liver is recurrently injured by …
Hepatitis B virus induces G1 phase arrest by regulating cell cycle genes in HepG2. 2.15 cells
T Wang, R Zhao, Y Wu, D Kong, L Zhang, D Wu, C Li… - Virology journal, 2011 - Springer
Background To investigate the effect of HBV on the proliferative ability of host cells and
explore the potential mechanism. Methods MTT, colony formation assay and tumourigenicity …
explore the potential mechanism. Methods MTT, colony formation assay and tumourigenicity …
The C-terminal region of the hepatitis B virus X protein is required for its stimulation of HBV replication in primary mouse hepatocytes
Hepatitis B virus (HBV) infection is an important risk factor for hepatocellular carcinoma
(HCC). The hepatitis B virus X protein (HBx), a multifunctional regulatory protein encoded by …
(HCC). The hepatitis B virus X protein (HBx), a multifunctional regulatory protein encoded by …