Hypertension is available at http://hyper. ahajournals. org DOI: 10.1161/HYP.
0000000000000047 e8 Hypertension September 2016 distributed trait. Therefore, defining …

Despite major advances in understanding the pathophysiology of hypertension and
availability of effective and safe antihypertensive drugs, suboptimal blood pressure (BP) …

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) protect against
cardiovascular disease by largely unknown mechanisms. We tested the hypothesis that EPA …

Cadmium (Cd) is an environmental toxicant of widespread exposure and pervasive toxicity.
Absorption, systemic transport and uptake of Cd are mediated by metal transporters that the …

We investigated 24-hour hemodynamic changes produced by salt loading and depletion in
8 salt-sensitive (SS) and 13 salt-resistant (SR) normotensive volunteers. After salt loading …

Hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE) is a cytochrome P450 (CYP)–derived
omega-hydroxylation metabolite of arachidonic acid. 20-HETE has been shown to play a …

Background—The CYP4A11 arachidonic acid monooxygenase oxidizes endogenous
arachidonic acid (AA) to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite with …

HETE, the ω-hydroxylation product of arachidonic acid catalyzed by enzymes of the
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …

20-Hydroxyeicosatetraenoic acid (20-HETE) plays an important role in the regulation of
renal tubular and vascular function and a deficiency in the renal formation of 20-HETE has …

Arachidonic acid is a major fatty acid that can be metabolized by the cytochrome P450
enzyme to a number of bioactive eicosanoids. A major metabolite of this oxidation is 20 …