In recent years, tissue engineering studies have proposed several approaches to
regenerate periodontium based on the use of three-dimensional (3D) tissue scaffolds alone …

Tooth and periodontal organoids from stem and progenitor cells represent a significant
advancement in regenerative dentistry, offering solutions for tooth loss and periodontal …

Background Periodontal ligament stem cells (PDLSCs) are important seed cells in tissue
engineering and clinical applications. They are the priority receptor cells for sensing various …

Fluid shear stress plays a pivotal role in regulating cellular behaviors, maintaining tissue
homeostasis, and driving disease progression. Cells in various tissues are specifically …

Simulated microgravity (SMG) poses substantial challenges to astronaut health, particularly
impacting osteoblast function and leading to disuse osteoporosis. This study investigates the …

The periodontal ligament (PDL) is crucial for maintaining the integrity and functionality of
tooth-supporting structures. Mechanical forces applied to the tooth during orthodontic tooth …

Angiomotin (Amot) family members, including Amot, Amot‑like protein 1 (Amotl1) and Amot‑
like protein 2 (Amotl2), have been found to interact with angiostatins. In addition, Amot family …

Orthodontic tooth movement (OTM) involves mechanical–biochemical signal transduction,
which results in tissue remodeling of the tooth–periodontium complex and the movement of …

Mechanical forces, including flow shear stress, govern fundamental cellular processes by
modulating nucleocytoplasmic transport of transcription factors like Yes‐associated Protein …

Human periodontal ligament (hPDL) is continuously exposed to mechanical forces that can
induce inflammatory responses in resident stem cells (hPDLSCs). Here, we review the …