Transition-metal-catalyzed silylation and borylation of C–H bonds for the synthesis and functionalization of complex molecules

IF Yu, JW Wilson, JF Hartwig - Chemical Reviews, 2023 - ACS Publications
The functionalization of C–H bonds in organic molecules containing functional groups has
been one of the holy grails of catalysis. One synthetically important approach to the diverse …

C H Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

J Yamaguchi, AD Yamaguchi… - Angewandte Chemie …, 2012 - Wiley Online Library
The direct functionalization of C H bonds in organic compounds has recently emerged as a
powerful and ideal method for the formation of carbon–carbon and carbon–heteroatom …

A perspective on late-stage aromatic C–H bond functionalization

L Zhang, T Ritter - Journal of the American Chemical Society, 2022 - ACS Publications
Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward
approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF …

C–H functionalization in the synthesis of amino acids and peptides

AFM Noisier, MA Brimble - Chemical Reviews, 2014 - ACS Publications
In recent years, the pharmaceutical market has experienced a paradigm shift; as small
molecules had long been thought of as the ultimate therapeutics, the use of biologics …

Iridium‐catalysed C− H borylation of heteroarenes: balancing steric and electronic regiocontrol

JS Wright, PJH Scott, PG Steel - … Chemie International Edition, 2021 - Wiley Online Library
The iridium‐catalysed borylation of aromatic C− H bonds has become the preferred method
for the synthesis of aromatic organoboron compounds. The reaction is highly efficient …

Postassembly modifications of peptides via metal-catalyzed C–H functionalization

HR Tong, B Li, G Li, G He, G Chen - CCS Chemistry, 2021 - chinesechemsoc.org
The growing importance of peptides and proteins in therapeutic and biomedical applications
has provided immense motivation toward the development of new ways to construct and …

Funktionalisierung von C‐H‐Bindungen: neue Synthesemethoden für Naturstoffe und Pharmazeutika

J Yamaguchi, AD Yamaguchi, K Itami - Angewandte Chemie, 2012 - Wiley Online Library
Die direkte Funktionalisierung von C‐H‐Bindungen in organischen Molekülen hat sich in
jüngster Zeit zu einer wirksamen und idealen Methode entwickelt, mit der Kohlenstoff …

Development and preclinical evaluation of [211At] PSAt-3-Ga: an inhibitor for targeted α-Therapy of prostate Cancer

M El Fakiri, N Ayada, M Müller, L Hvass… - Journal of Nuclear …, 2024 - jnm.snmjournals.org
The application of prostate-specific membrane antigen (PSMA)–targeted α-therapy is a
promising alternative to β−-particle–based treatments. 211At is among the potential α …

Recent Advances on Amino Acid Modifications via C–H Functionalization and Decarboxylative Functionalization Strategies

S Mondal, S Chowdhury - Advanced Synthesis & Catalysis, 2018 - Wiley Online Library
Over the recent decade tremendous interest has been developed on the synthetic
modification of natural as well as non‐proteinogenic amino acids and non‐natural linkages …

Site‐Selective C–H Bond Activation/Functionalization of Alpha‐Amino Acids and Peptide‐Like Derivatives

T Brandhofer… - European Journal of …, 2018 - Wiley Online Library
Amino acids and peptides play an important role in nature, as well as in organic and
pharmaceutical chemistry. Therefore, the easy, straightforward and versatile access of …