Imaging brain microstructure with diffusion MRI: practicality and applications

DC Alexander, TB Dyrby, M Nilsson… - NMR in …, 2019 - Wiley Online Library
This article gives an overview of microstructure imaging of the brain with diffusion MRI and
reviews the state of the art. The microstructure‐imaging paradigm aims to estimate and map …

Studying neuroanatomy using MRI

JP Lerch, AJW Van Der Kouwe, A Raznahan… - Nature …, 2017 - nature.com
The study of neuroanatomy using imaging enables key insights into how our brains function,
are shaped by genes and environment, and change with development, aging and disease …

[HTML][HTML] Neurite Exchange Imaging (NEXI): A minimal model of diffusion in gray matter with inter-compartment water exchange

IO Jelescu, A de Skowronski, F Geffroy, M Palombo… - NeuroImage, 2022 - Elsevier
Biophysical models of diffusion in white matter have been center-stage over the past two
decades and are essentially based on what is now commonly referred to as the “Standard …

Q-space trajectory imaging for multidimensional diffusion MRI of the human brain

CF Westin, H Knutsson, O Pasternak… - Neuroimage, 2016 - Elsevier
This work describes a new diffusion MR framework for imaging and modeling of
microstructure that we call q-space trajectory imaging (QTI). The QTI framework consists of …

[HTML][HTML] Challenges for biophysical modeling of microstructure

IO Jelescu, M Palombo, F Bagnato… - Journal of Neuroscience …, 2020 - Elsevier
The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

[HTML][HTML] Neurite density imaging versus imaging of microscopic anisotropy in diffusion MRI: a model comparison using spherical tensor encoding

B Lampinen, F Szczepankiewicz, J Mårtensson… - Neuroimage, 2017 - Elsevier
In diffusion MRI (dMRI), microscopic diffusion anisotropy can be obscured by orientation
dispersion. Separation of these properties is of high importance, since it could allow dMRI to …

[HTML][HTML] Diffusion time dependence, power-law scaling, and exchange in gray matter

JL Olesen, L Østergaard, N Shemesh, SN Jespersen - NeuroImage, 2022 - Elsevier
Characterizing neural tissue microstructure is a critical goal for future neuroimaging.
Diffusion MRI (dMRI) provides contrasts that reflect diffusing spins' interactions with myriad …

[HTML][HTML] Quantification of microscopic diffusion anisotropy disentangles effects of orientation dispersion from microstructure: applications in healthy volunteers and in …

F Szczepankiewicz, S Lasič, D van Westen… - Neuroimage, 2015 - Elsevier
The anisotropy of water diffusion in brain tissue is affected by both disease and
development. This change can be detected using diffusion MRI and is often quantified by the …

Microanisotropy imaging: quantification of microscopic diffusion anisotropy and orientational order parameter by diffusion MRI with magic-angle spinning of the q …

S Lasič, F Szczepankiewicz, S Eriksson… - Frontiers in …, 2014 - frontiersin.org
Diffusion tensor imaging (DTI) is the method of choice for non-invasive investigations of the
structure of human brain white matter (WM). The results are conventionally reported as maps …

[HTML][HTML] The link between diffusion MRI and tumor heterogeneity: Map** cell eccentricity and density by diffusional variance decomposition (DIVIDE)

F Szczepankiewicz, D van Westen, E Englund… - Neuroimage, 2016 - Elsevier
The structural heterogeneity of tumor tissue can be probed by diffusion MRI (dMRI) in terms
of the variance of apparent diffusivities within a voxel. However, the link between the …