The glycosylation in SARS-CoV-2 and its receptor ACE2

Y Gong, S Qin, L Dai, Z Tian - Signal Transduction and Targeted …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …

[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

GY Oudit, K Wang, A Viveiros, MJ Kellner… - Cell, 2023 - cell.com
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …

Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain

KG Nabel, SA Clark, S Shankar, J Pan, LE Clark… - Science, 2021 - science.org
Many studies have examined the impact of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variants on neutralizing antibody activity after they have become dominant …

Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level

R Zhu, D Canena, M Sikora, M Klausberger… - nature …, 2022 - nature.com
Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …

The flexibility of ACE2 in the context of SARS-CoV-2 infection

EP Barros, L Casalino, Z Gaieb, AC Dommer, Y Wang… - Biophysical journal, 2021 - cell.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has swept over the world in
the past months, causing significant loss of life and consequences to human health …

Molecular insights into receptor binding energetics and neutralization of SARS-CoV-2 variants

M Koehler, A Ray, RA Moreira, B Juniku… - Nature …, 2021 - nature.com
Despite an unprecedented global gain in knowledge since the emergence of SARS-CoV-2,
almost all mechanistic knowledge related to the molecular and cellular details of viral …

Protein post-translational modification in SARS-CoV-2 and host interaction

N Cheng, M Liu, W Li, BY Sun, D Liu, G Wang… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2 can cause lung diseases, such as pneumonia and acute respiratory distress
syndrome, and multi-system dysfunction. Post-translational modifications (PTMs) related to …

Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation

H Nguyen, HL Nguyen, PD Lan, NQ Thai… - Chemical Society …, 2023 - pubs.rsc.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

Endothelial cells are not productively infected by SARS‐CoV‐2

L Schimmel, KY Chew, CJ Stocks… - Clinical & …, 2021 - Wiley Online Library
Objectives Thrombotic and microvascular complications are frequently seen in deceased
COVID‐19 patients. However, whether this is caused by direct viral infection of the …