Alzheimer is an irreversible progressive neurodegenerative disease that causes failure of
cerebral neurons and disability of the affected person to practice normal daily life activities …

Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex
behaviors such as cognition, movement, and reward, making them ideally situated as …

Alzheimer's disease (AD) remains a major cause of morbidity and mortality worldwide, and
despite extensive research, only a few drugs are available for management of the disease …

An unfortunate result of the rapid rise in geriatric populations worldwide is the increasing
prevalence of age-related cognitive disorders such as Alzheimer's disease (AD). AD is a …

Activation of muscarinic M 1 receptor (M 1 R) is a promising approach for improving
cognitive impairment in Alzheimer's disease. However, an M 1 R-selective positive allosteric …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

The M1/M4 muscarinic acetylcholine receptor agonist xanomeline can significantly improve
the cognitive function, but the intolerable side effects limit its clinical usefulness. Our recent …

Abstract The M1/M4-preferring muscarinic agonist xanomeline was found to have some
benefit in the treatment of the memory impairment of Alzheimer's disease (AD), but side …

Agonists of M1 muscarinic acetylcholine receptors are promising therapeutic agents for the
treatment of Alzheimer's disease (AD). An example of one of these agents is xanomeline …

Objective To characterize the function of a new xanomeline-derived M1 agonist, 3-[3-(3-
florophenyl-2-propyn-1-ylthio)-1, 2, 5-thiadiazol-4-yl]-1, 2, 5, 6-tetrahydro-1-methylpyridine …