Transcriptional elongation control in developmental gene expression, aging, and disease
The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …
regulation of gene expression in response to developmental and environmental cues in …
Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones
Ferroptosis, a cell death process driven by iron-dependent phospholipid peroxidation, has
been implicated in various diseases. There are two major surveillance mechanisms to …
been implicated in various diseases. There are two major surveillance mechanisms to …
Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential
M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …
R-loop-dependent promoter-proximal termination ensures genome stability
C Xu, C Li, J Chen, Y **ong, Z Qiao, P Fan, C Li, S Ma… - Nature, 2023 - nature.com
The proper regulation of transcription is essential for maintaining genome integrity and
executing other downstream cellular functions,. Here we identify a stable association …
executing other downstream cellular functions,. Here we identify a stable association …
[HTML][HTML] Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems
Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human
cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the …
cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the …
[HTML][HTML] An epigenetic barrier sets the timing of human neuronal maturation
The pace of human brain development is highly protracted compared with most other
species,,,,,–. The maturation of cortical neurons is particularly slow, taking months to years to …
species,,,,,–. The maturation of cortical neurons is particularly slow, taking months to years to …
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements
Gene expression is controlled by dynamic localization of thousands of regulatory proteins to
precise genomic regions. Understanding this cell type-specific process has been a …
precise genomic regions. Understanding this cell type-specific process has been a …
Non-canonical MLL1 activity regulates centromeric phase separation and genome stability
Epigenetic dysregulation is a prominent feature in cancer, as exemplified by frequent
mutations in chromatin regulators, including the MLL/KMT2 family of histone …
mutations in chromatin regulators, including the MLL/KMT2 family of histone …
Collisions of RNA polymerases behind the replication fork promote alternative RNA splicing in newly replicated chromatin
F Bruno, C Coronel-Guisado, C González-Aguilera - Molecular Cell, 2024 - cell.com
DNA replication produces a global disorganization of chromatin structure that takes hours to
be restored. However, how these chromatin rearrangements affect the regulation of gene …
be restored. However, how these chromatin rearrangements affect the regulation of gene …
Mechanisms of heat stress-induced transcriptional memory
Transcriptional memory allows organisms to store information about transcriptional
reprogramming in response to a stimulus. In plants, this often involves the response to an …
reprogramming in response to a stimulus. In plants, this often involves the response to an …