In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall
inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that …

Next is a granulation or cellular proliferation phase. Growth factors are subsequently
released from platelets, leukocytes, and SMCs, which stimulate migration of SMCs from the …

Carbon monoxide (CO), one of the products of heme oxygenase action on heme, prevents
arteriosclerotic lesions that occur following aorta transplantation; pre-exposure to 250 parts …

Abstract Heme oxygenase (HO-1, encoded by Hmox1) is an inducible protein activated in
systemic inflammatory conditions by oxidant stress. Vascular injury is characterized by a …

Entry into and progression of vascular cells through the cell cycle is considered a key event
in vascular proliferative diseases. Multiple growth factors and cytokines have been found to …

Vascular gene transfer potentially offers new treatments for cardiovascular diseases. It can
be used to overexpress therapeutically important proteins and correct genetic defects, and to …

Understanding molecular mechanisms involved in vascular aging is essential to develop
novel interventional strategies for treatment and prevention of age-related vascular …

Therapeutic modulation of vascular cell proliferation and migration is essential for the
effective inhibition of angiogenesis in cancer or its induction in cardiovascular disease. The …

Cardiovascular events are the most frequent cause of death in patients with chronic renal
failure (1–2). Heterotopic calcification of blood vessel walls occurs frequently with advanced …

The cyclin‐dependent kinase inhibitor, p27 Kip1, which regulates cell cycle progression, is
controlled by its subcellular localization and subsequent degradation. p27 Kip1 is …