RAGE and its ligands: molecular interplay between glycation, inflammation, and hallmarks of cancer—a review

G Palanissami, SFD Paul - Hormones and Cancer, 2018 - Springer
Risk of cancer especially of colon, breast, and pancreas is high in diabetic and obese
patients, with potential involvement of augmented expression of RAGE (receptor for …

AGE-RAGE synergy influences programmed cell death signaling to promote cancer

BN Waghela, FU Vaidya, K Ranjan, AS Chhipa… - Molecular and Cellular …, 2021 - Springer
Advanced glycation end products (AGEs) are formed as a result of non-enzymatic reaction
between the free reducing sugars and proteins, lipids, or nucleic acids. AGEs are …

Molecular characteristics of RAGE and advances in small-molecule inhibitors

HJ Kim, MS Jeong, SB Jang - International journal of molecular sciences, 2021 - mdpi.com
Receptor for advanced glycation end-products (RAGE) is a member of the immunoglobulin
superfamily. RAGE binds and mediates cellular responses to a range of DAMPs (damage …

Insulin/IGF axis and the Receptor for Advanced Glycation End Products: role in meta-inflammation and potential in cancer therapy

V Vella, R Lappano, E Bonavita, M Maggiolini… - Endocrine …, 2023 - academic.oup.com
In metabolic conditions such as obesity and diabetes, which are associated with
deregulated signaling of the insulin/insulin-like growth factor system (IIGFs), inflammation …

RAGE and its ligands: from pathogenesis to therapeutics

N Jangde, R Ray, V Rai - Critical reviews in biochemistry and …, 2020 - Taylor & Francis
Receptor for advanced glycation end products (RAGE) is an immunoglobulin-like receptor
present on cell surface. RAGE binds to an array of structurally diverse ligands, acts as a …

Role and mechanisms of RAGE-ligand complexes and RAGE-inhibitors in cancer progression

AH El-Far, G Sroga, SK Al Jaouni… - International journal of …, 2020 - mdpi.com
Interactions of the receptor for advanced glycation end product (RAGE) and its ligands in the
context of their role in diabetes mellitus, inflammation, and carcinogenesis have been …

[HTML][HTML] Food advanced glycation end products as potential endocrine disruptors: An emerging threat to contemporary and future generation

G Ravichandran, DK Lakshmanan, K Raju… - Environment …, 2019 - Elsevier
Mankind exposure to chemicals in the past century has increased dramatically throughout
environment. There is no question that chemicals interfere with the physiology of biological …

Diabetes and pancreatic cancer—A dangerous liaison relying on carbonyl stress

S Menini, C Iacobini, M Vitale, C Pesce, G Pugliese - Cancers, 2021 - mdpi.com
Simple Summary Diabetic people have an increased risk of develo** several types of
cancers, particularly pancreatic cancer. The higher availability of glucose and/or lipids that …

The dual-role of methylglyoxal in tumor progression–novel therapeutic approaches

A Leone, C Nigro, A Nicolò, I Prevenzano… - Frontiers in …, 2021 - frontiersin.org
One of the hallmarks of cancer cells is their metabolic reprogramming, which includes the
preference for the use of anaerobic glycolysis to produce energy, even in presence of …

Dietary advanced glycation end products and the risk of postmenopausal breast cancer in the National Institutes of Health‐AARP diet and health study

LL Peterson, S Park, Y Park, GA Colditz, N Anbardar… - Cancer, 2020 - Wiley Online Library
Background Advanced glycation end products (AGEs) are reactive metabolites produced as
a by‐product of sugar metabolism and are consumed through the diet in high‐fat and highly …