Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC)
Topoisomerases are essential enzymes solving DNA topological problems such as
supercoils, knots and catenanes that arise from replication, transcription, chromatin …
supercoils, knots and catenanes that arise from replication, transcription, chromatin …
[HTML][HTML] The chromatin response to double-strand DNA breaks and their repair
Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
Endogenous DNA 3′ blocks are vulnerabilities for BRCA1 and BRCA2 deficiency and are reversed by the APE2 nuclease
The APEX2 gene encodes APE2, a nuclease related to APE1, the apurinic/apyrimidinic
endonuclease acting in base excision repair. Loss of APE2 is lethal in cells with mutated …
endonuclease acting in base excision repair. Loss of APE2 is lethal in cells with mutated …
Synthesis and comprehensive spectroscopic (X-ray, NMR, FTIR, UV–Vis), quantum chemical and molecular docking investigation of 3-acetyl-4‑hydroxy‑2-oxo-2H …
In the present study, the structural, spectroscopic (FT-IR, NMR, and UV–Vis) and electronic
properties of newly synthesized 3-acetyl-4‑hydroxy‑2-oxo-2H-chromen-7-yl acetate …
properties of newly synthesized 3-acetyl-4‑hydroxy‑2-oxo-2H-chromen-7-yl acetate …
Transcription-coupled DNA double-strand break repair
The genomic DNA is constantly under attack by cellular and/or environmental factors.
Fortunately, the cell is armed to safeguard its genome by various mechanisms such as …
Fortunately, the cell is armed to safeguard its genome by various mechanisms such as …
Dual DNA topoisomerase 1 and tyrosyl‐DNA phosphodiesterase 1 inhibition for improved anticancer activity
A Zakharenko, N Dyrkheeva… - Medicinal Research …, 2019 - Wiley Online Library
Abstract Tyrosyl‐DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that catalyzes
the hydrolysis of the phosphodiester bond in the DNA‐topoisomerase 1 (Top1) covalent …
the hydrolysis of the phosphodiester bond in the DNA‐topoisomerase 1 (Top1) covalent …
Targeted sulfur (VI) fluoride exchange-mediated covalent modification of a tyrosine residue in the catalytic pocket of tyrosyl-DNA phosphodiesterase 1
Develo** effective inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1
(TDP1) has been challenging because of the enzyme shallow catalytic pocket and non …
(TDP1) has been challenging because of the enzyme shallow catalytic pocket and non …
From the TOP: Formation, recognition and resolution of topoisomerase DNA protein crosslinks
JL Wojtaszek, RS Williams - DNA repair, 2024 - Elsevier
Since the report of “DNA untwisting” activity in 1972,∼ 50 years of research has revealed
seven topoisomerases in humans (TOP1, TOP1mt, TOP2α, TOP2β, TOP3α, TOP3β and …
seven topoisomerases in humans (TOP1, TOP1mt, TOP2α, TOP2β, TOP3α, TOP3β and …
N-terminal domain of tyrosyl-DNA phosphodiesterase I regulates topoisomerase I-induced toxicity in cells
Abstract Tyrosyl-DNA phosphodiesterase I (Tdp1) hydrolyzes phosphodiester-linked
adducts from both ends of DNA. This includes the topoisomerase I (TOP1)-DNA covalent …
adducts from both ends of DNA. This includes the topoisomerase I (TOP1)-DNA covalent …
Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a member of the phospholipase D family of
enzymes, which catalyzes the removal of both 3′-and 5′-DNA phosphodiester adducts …
enzymes, which catalyzes the removal of both 3′-and 5′-DNA phosphodiester adducts …