Frailty: implications for clinical practice and public health

EO Hoogendijk, J Afilalo, KE Ensrud, P Kowal, G Onder… - The Lancet, 2019 - thelancet.com
Frailty is an emerging global health burden, with major implications for clinical practice and
public health. The prevalence of frailty is expected to rise alongside rapid growth in the …

Management of frailty: opportunities, challenges, and future directions

E Dent, FC Martin, H Bergman, J Woo… - The Lancet, 2019 - thelancet.com
Frailty is a complex age-related clinical condition characterised by a decline in physiological
capacity across several organ systems, with a resultant increased susceptibility to stressors …

Development and validation of an electronic frailty index using routine primary care electronic health record data

A Clegg, C Bates, J Young, R Ryan, L Nichols… - Age and …, 2016 - academic.oup.com
Background: frailty is an especially problematic expression of population ageing.
International guidelines recommend routine identification of frailty to provide evidence …

Frailty index and all-cause and cause-specific mortality in Chinese adults: a prospective cohort study

J Fan, C Yu, Y Guo, Z Bian, Z Sun, L Yang… - The Lancet Public …, 2020 - thelancet.com
Background The fraily index is a useful proxy measure of accelerated biological ageing and
in estimating all-cause and cause-specific mortality in older individuals in European and US …

Frailty and cancer: implications for oncology surgery, medical oncology, and radiation oncology

CG Ethun, MA Bilen, AB Jani, SK Maithel… - CA: a cancer journal …, 2017 - Wiley Online Library
Answer questions and earn CME/CNE The concept of frailty has become increasingly
recognized as one of the most important issues in health care and health outcomes and is of …

Frailty syndrome: implications and challenges for health care policy

G Kojima, AEM Liljas, S Iliffe - Risk management and healthcare …, 2019 - Taylor & Francis
Older adults are a highly heterogeneous group with variable health and functional life
courses. Frailty has received increasing scientific attention as a potential explanation of the …

Frailty screening and interventions: considerations for clinical practice

J Walston, B Buta, QL Xue - Clinics in geriatric medicine, 2018 - geriatric.theclinics.com
Over the past 100 years, advances in medicine and public health have led to a nearly 2-fold
increase in average lifespan. 1 Approximately 8.5% of the global population is 65 years or …

Frailty for perioperative clinicians: a narrative review

DI McIsaac, DB MacDonald, SD Aucoin - Anesthesia & Analgesia, 2020 - journals.lww.com
Frailty is a multidimensional syndrome characterized by decreased reserve and diminished
resistance to stressors. People with frailty are vulnerable to stressors, and exposure to the …

Efficacy of reduced-intensity chemotherapy with oxaliplatin and capecitabine on quality of life and cancer control among older and frail patients with advanced …

PS Hall, D Swinson, DA Cairns, JS Waters… - JAMA …, 2021 - jamanetwork.com
Importance Older and/or frail patients are underrepresented in landmark cancer trials.
Tailored research is needed to address this evidence gap. Objective The GO2 randomized …

Frailty and cancer: current perspectives on assessment and monitoring

V Goede - Clinical interventions in aging, 2023 - Taylor & Francis
Frailty, an age-related condition of increased vulnerability to acute endogenous or
exogenous stressors, is a key barrier to successful treatment of cancer in older people. In …