Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

Risk factors and the natural history of accelerated knee osteoarthritis: a narrative review

JB Driban, MS Harkey, MF Barbe, RJ Ward… - BMC musculoskeletal …, 2020 - Springer
Background Osteoarthritis is generally a slowly progressive disorder. However, at least 1 in
7 people with incident knee osteoarthritis develop an abrupt progression to advanced-stage …

The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis

MG Wang, P Seale, D Furman - npj Aging, 2024 - nature.com
Osteoarthritis (OA) is the most common form of arthritis and accounts for nearly $140 billion
in annual healthcare expenditures only in the United States. Obesity, aging, and joint injury …

Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee

J **e, Z Huang, X Yu, L Zhou, F Pei - Cytokine & growth factor reviews, 2019 - Elsevier
Osteoarthritis (OA) is the most common form of arthritic disease, leading to disability and
impaired quality of life and no curative treatments exist. Increasing evidence indicates that …

Role of mesenchymal stem cells and their paracrine mediators in macrophage polarization: an approach to reduce inflammation in osteoarthritis

SS Kuppa, HK Kim, JY Kang, SC Lee… - International Journal of …, 2022 - mdpi.com
Osteoarthritis (OA) is a low-grade inflammatory disorder of the joints that causes
deterioration of the cartilage, bone remodeling, formation of osteophytes, meniscal damage …

Post-traumatic knee osteoarthritis; the role of inflammation and hemarthrosis on disease progression

BJ Evers, MHJ Van Den Bosch, AB Blom… - Frontiers in …, 2022 - frontiersin.org
Knee injuries such as anterior cruciate ligament ruptures and meniscal injury are common
and are most frequently sustained by young and active individuals. Knee injuries will lead to …

Magnetic resonance imaging assessments for knee segmentation and their use in combination with machine/deep learning as predictors of early osteoarthritis …

J Martel-Pelletier, P Paiement… - Therapeutic Advances …, 2023 - journals.sagepub.com
Knee osteoarthritis (OA) is a prevalent and disabling disease that can develop over
decades. This disease is heterogeneous and involves structural changes in the whole joint …

Role of adipose tissues in osteoarthritis

N Zapata-Linares, F Eymard… - Current Opinion in …, 2021 - journals.lww.com
The recent description of adipose tissues of various phenotypes within an osteoarthritic joint
allows us to evoke their direct involvement in the initiation and progression of the …

Interpretation of cartilage damage at routine clinical MRI: how to match arthroscopic findings

BK Markhardt, BK Huang, AM Spiker, EY Chang - Radiographics, 2022 - pubs.rsna.org
This review is intended to aid in the interpretation of damage to the articular cartilage at
routine clinical MRI to improve clinical management. Relevant facets of the histologic and …

Synovium and infrapatellar fat pad share common mesenchymal progenitors and undergo coordinated changes in osteoarthritis

J Li, T Gui, L Yao, H Guo, YL Lin, J Lu… - Journal of Bone and …, 2024 - academic.oup.com
Osteoarthritis (OA) affects multiple tissues in the knee joint, including the synovium and intra-
articular adipose tissue (IAAT) that are attached to each other. However, whether these two …