The latest in animal models of pulmonary hypertension and right ventricular failure

O Boucherat, V Agrawal, A Lawrie, S Bonnet - Circulation research, 2022‏ - ahajournals.org
Pulmonary hypertension (PH) describes heterogeneous population of patients with a mean
pulmonary arterial pressure> 20 mm Hg. Rarely, PH presents as a primary disorder but is …

Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension

M Rabinovitch, C Guignabert, M Humbert… - Circulation …, 2014‏ - ahajournals.org
This review summarizes an expanding body of knowledge indicating that failure to resolve
inflammation and altered immune processes underlie the development of pulmonary arterial …

The renin‐angiotensin‐aldosterone system in vascular inflammation and remodeling

M Pacurari, R Kafoury, PB Tchounwou… - International journal …, 2014‏ - Wiley Online Library
The RAAS through its physiological effectors plays a key role in promoting and maintaining
inflammation. Inflammation is an important mechanism in the development and progression …

Anti-TNFα therapy in inflammatory lung diseases

R Malaviya, JD Laskin, DL Laskin - Pharmacology & therapeutics, 2017‏ - Elsevier
Increased levels of tumor necrosis factor (TNF) α have been linked to a number of
pulmonary inflammatory diseases including asthma, chronic obstructive pulmonary disease …

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

LA Hurst, BJ Dunmore, L Long, A Crosby… - Nature …, 2017‏ - nature.com
Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor
(BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH). Although …

Measuring the lung function in the mouse: the challenge of size

CG Irvin, JHT Bates - Respiratory research, 2003‏ - Springer
Measurement of the effects of drugs, mediators and infectious agents on various models of
lung disease, as well as assessment of lung function in the intact mouse has the potential for …

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

P Gasse, C Mary, I Guenon, N Noulin, S Charron… - The Journal of clinical …, 2007‏ - jci.org
The molecular mechanisms of acute lung injury resulting in inflammation and fibrosis are not
well established. Here we investigate the roles of the IL-1 receptor 1 (IL-1R1) and the …

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease

T Yoshida, RM Tuder - Physiological reviews, 2007‏ - journals.physiology.org
Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …

IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger

S Ferretti, O Bonneau, GR Dubois… - The Journal of …, 2003‏ - journals.aai.org
IL-17 is a cytokine implicated in the regulation of inflammation. We investigated the role of
this cytokine in neutrophil recruitment using a model of LPS-induced lung inflammation in …

Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension

R Tamosiuniene, W Tian, G Dhillon, L Wang… - Circulation …, 2011‏ - ahajournals.org
Rationale: Pulmonary arterial hypertension (PAH) is an incurable disease associated with
viral infections and connective tissue diseases. The relationship between inflammation and …