Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Molecularly targeted cancer therapies substantially improve patient outcomes, although the
durability of their effectiveness can be limited. Resistance to these therapies is often related …

Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

The nuclear factor-κB (NF-κB) signaling pathway is one of the most well-studied pathways
related to inflammation, and its involvement in aging has attracted considerable attention. As …

The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

Originally discovered in C. elegans, LIN28 is an evolutionarily conserved zinc finger RNA-
binding protein (RBP) that post-transcriptionally regulates genes involved in developmental …

Elucidation of protein-protein interactions (PPIs) represents one of the most important
methods in biomedical research. Recently, PPIs have started to be exploited for drug …

Recently, the development of protein degraders (protein-degrading compounds) has
prominently progressed. There are two remarkable classes of protein degraders: proteolysis …

RAS oncogenic mutations are pivotal drivers of tumorigenesis. Ubiquitination modulates
RAS functions, including activation, stability, and localization. While several E3 ligases …

ABSTRACT TFEB and TFE3 belong to the MiT/TFE family of transcription factors that bind
identical DNA responsive elements in the regulatory regions of target genes. They are …