The recovery of an intact epithelium following lung injury is critical for restoration of lung
homeostasis. The initial processes following injury include an acute inflammatory response …

Morbidity and mortality have declined only modestly in patients with clinical acute lung injury
(ALI) and acute respiratory distress syndrome (ARDS), despite extensive research into the …

Introduction Idiopathic pulmonary fibrosis is a progressive diffuse parenchymal lung disorder
of unknown etiology. Mesenchymal stem cell (MSC)-based therapy is a novel approach with …

Idiopathic pulmonary fibrosis is a major cause of death with few treatment options. Here, we
demonstrate the therapeutic efficacy for lung fibrosis of adult lung cell transplantation using …

Background Although progenitor cells have been described in distinct anatomical regions of
the lung, description of resident stem cells has remained elusive. Methods Surgical lung …

EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

Most current drug screening assays used to identify new drug candidates are 2D cell-based
systems, even though such in vitro assays do not adequately re-create the in vivo complexity …

Lung diseases remain a significant and devastating cause of morbidity and mortality
worldwide. In contrast to many other major diseases, lung diseases notably chronic …

Purpose To explore the feasibility of bone marrow mesenchymal stem cells (MSCs)
transdifferentiating into corneal epithelial cells in a limbal stem cell deficiency (LSCD) model …

Despite extensive research into the pathogenesis of acute lung injury and the acute
respiratory distress syndrome (ALI/ARDS), mortality remains high at approximately 40 …