Mass spectrometry is a vital tool for molecular characterization, and the allied technique of
ion mobility is enhancing many areas of (bio) chemical analysis. Strong synergy arises …

Pathological protein and peptide aggregation are key events in a number of chronic and
devastating neurodegenerative conditions including dementias such as Alzheimer's and …

Alzheimer's disease (AD) is characterized by multiple, intertwined pathological features,
including amyloid-β (Aβ) aggregation, metal ion dyshomeostasis, and oxidative stress. We …

Proper function of lysosomes is particularly important in neurons, as they cannot dilute
accumulated toxic molecules and aggregates by cell division. Thus, impairment of lysosomal …

The characterization of amyloid-beta peptide (Aβ) oligomer forms and structures is crucial to
the advancement in the field of Alzheimer´ s disease (AD). Here we report a critical …

Probing the conformational changes of amyloid beta (Aβ) peptide aggregation is
challenging owing to the vast heterogeneity of the resulting soluble aggregates. To …

Interfacing ion mobility spectrometry to mass spectrometry (IMS–MS) has enabled mass
spectrometric analyses to extend into an extra dimension, providing unrivalled separation …

Amyloid cascades leading to peptide β-sheet fibrils and plaques are central to many
important diseases. Recently, intermediate assemblies of these cascades were identified as …

The early oligomerization of amyloid β-protein (Aβ) has been shown to be an important
event in the pathology of Alzheimer's disease (AD). Designing small molecule inhibitors …

Misfolding and aggregation of amyloid peptides are the key pathological events in many
neurodegenerative diseases. The development of effective inhibitors and drugs to prevent …