Catalytic reactions promoted by N-heterocyclic carbenes (NHCs) have exploded in
popularity since 2004 when several reports described new fundamental reactions that …

N-Heterocyclic carbene (NHC) organocatalysis has been recognized as a powerful synthetic
strategy for the construction of a wide variety of medicinally and biologically important …

A convergent, catalytic asymmetric formal [4+ 2] annulation for the synthesis of
dihydroquinolones has been developed. Carboxylic acids can be employed as precursors to …

A general approach for preparation of two types of polyfunctionalized 3-
trifluoromethylpyrazoles is reported. The protocol comprises (3+ 2)-cycloaddition of the in …

N-2, 2, 2-Trifluoroethylisatin ketimines with β-trifluoromethyl enones, 3-trifluoroethylidene
oxindole, and 3-trifluoroethylidene benzofuranone can undergo asymmetric [3+ 2] …

This review is focused on the enantioselective synthesis of 3, 4-dihydropyran derivatives,
whose importance as chiral building blocks in the synthesis of bioactive molecules and …

Given the important agricultural and medicinal application of optically pure heterocycles
bearing a trifluoromethyl group at the stereogenic carbon center in the heterocyclic …

The broad prospects of trifluoromethylated compounds in materials science, agricultural
chemistry, and pharmaceutical chemistry have stimulated the rapid development of …

Owing to the unique properties of fluorine-containing moieties in the pharmaceuticals,
agrochemicals and materials, several synthetic efforts (ie, enzymatic resolution, transition …

The trifluoromethyl (CF3) group is an advantageous structural motif in various biologically
active molecules as well as materials, which is depicted by steadily increasing demand from …