In one decade, immunotherapy based on immune checkpoint blockades (ICBs) has become
a new pillar of cancer treatment following surgery, radiation, chemotherapy, and targeted …

Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer,
negatively expresses estrogen receptor, progesterone receptor, and the human epidermal …

Nanozyme-mediated tumor catalytic therapy has recently garnered attention as a means of
destroying tumor cells and eliciting anti-tumor immune responses. Herein, a copper-doped …

Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that is generally
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …

The diverse cell types of an organ have a highly structured organization to enable their
efficient and correct function. To fully appreciate gene functions in a given cell type, one …

Background Recently, therapeutic antibodies against programmed cell death 1 (PD-1) and
its ligand (PD-L1) have exerted potent anticancer effect in a variety of tumors. However …

As a nontraditional T-cell subgroup, γδT cells have gained popularity in the field of
immunotherapy in recent years. They have extraordinary antitumor potential and prospects …

Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

Approaches capable of simultaneously treating cancer and protecting susceptible patients
from lethal infections such as coronavirus disease 2019, are highly desirable but prove to be …

As a newly identified checkpoint, T cell immunoreceptor with immunoglobulin and tyrosine-
based inhibitory motif (ITIM) domain (TIGIT) is highly expressed on CD4+ T cells, CD8+ T …