Using automated patch clamp electrophysiology platforms in pain‐related ion channel research: insights from industry and academia
Automated patch clamp (APC) technology was first developed at the turn of the millennium.
The increased throughput it afforded promised a new paradigm in ion channel recordings …
The increased throughput it afforded promised a new paradigm in ion channel recordings …
Activation of alpha7 nicotinic and NMDA receptors is necessary for performance in a working memory task
D Phenis, SA Vunck, V Valentini, H Arias… - …, 2020 - Springer
Rationale Working memory deficits are present in schizophrenia (SZ) but remain
insufficiently resolved by medications. Similar cognitive dysfunctions can be produced …
insufficiently resolved by medications. Similar cognitive dysfunctions can be produced …
3-Furan-2-yl-Np-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic receptor, reverses schizophrenia-like cognitive and social deficits in rats
A Potasiewicz, M Hołuj, T Kos, P Popik, HR Arias… - …, 2017 - Elsevier
The cognitive impairments and negative symptoms experienced by schizophrenia patients
still await effective treatment. Alpha7 nicotinic acetylcholine receptors (α7 nAChRs) have …
still await effective treatment. Alpha7 nicotinic acetylcholine receptors (α7 nAChRs) have …
In silico modeling of the α7 nicotinic acetylcholine receptor: new pharmacological challenges associated with multiple modes of signaling
A Gulsevin, RL Papke… - Mini reviews in medicinal …, 2020 - ingentaconnect.com
The α7 nicotinic acetylcholine receptor is a homopentameric ion-channel of the Cys-loop
superfamily characterized by its low probability of opening, high calcium permeability, and …
superfamily characterized by its low probability of opening, high calcium permeability, and …
Molecular interactions of type I and type II positive allosteric modulators with the human α7 nicotinic acetylcholine receptor: an in silico study
KM Targowska-Duda, AA Kaczor… - Journal of …, 2019 - Taylor & Francis
The binding site locations and structural components for type I and type II positive allosteric
modulators (PAMs) of the α7 nicotinic acetylcholine receptor (nAChR) have not been fully …
modulators (PAMs) of the α7 nicotinic acetylcholine receptor (nAChR) have not been fully …
Positive allosteric modulators of α7* or β2* nicotinic acetylcholine receptors trigger different kinase pathways in mitochondria
K Uspenska, O Lykhmus, HR Arias, S Pons… - … International Journal of …, 2018 - Elsevier
Mitochondrial nicotinic acetylcholine receptors (nAChRs) regulate the early stage of
mitochondria-driven apoptosis, including cytochrome c release. Mitochondrial nAChR …
mitochondria-driven apoptosis, including cytochrome c release. Mitochondrial nAChR …
Significance of the nicotinic alpha7 receptor in cognition and antipsychotic-like behavior in the rat
MLG Wadenberg, D Manetti, MN Romanelli… - Behavioural Brain …, 2017 - Elsevier
Schizophrenic (SCH) patients show cognitive impairment in attentional performance.
Positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (nAChRs) such …
Positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (nAChRs) such …
3-Furan-2-yl-Np-tolyl-acrylamide, a highly selective positive allosteric modulator of α7 nicotinic receptors, produces anxiolytic-like activity in mice
KM Targowska-Duda, B Budzynska… - Journal of …, 2019 - journals.sagepub.com
Background: Several lines of investigations support the idea that nicotinic acetylcholine
receptors modulate neuronal pathways involved in anxiety and depression. Aims: The …
receptors modulate neuronal pathways involved in anxiety and depression. Aims: The …
Molecular modelling studies on ɑ7 nicotinic receptor allosteric modulators yields novel filter-based virtual screening protocol
S Al Rawashdah, A Hamrouni, B Sadek, R Amer… - Journal of Molecular …, 2019 - Elsevier
The ɑ7 receptor is a member in the nicotinic acetylcholine receptor (nAChR) which has
been implicated in several neurological disorders. Beside normal agonists and antagonists …
been implicated in several neurological disorders. Beside normal agonists and antagonists …
Cholinergic protection in ischemic brain injury
VV Uteshev - Neuroprotective Therapy for Stroke and Ischemic …, 2017 - Springer
The cholinergic system is essential for maintenance of cognitive, autonomic, and immune
homeostasis in mammals. Existing preclinical studies suggest that endogenous cholinergic …
homeostasis in mammals. Existing preclinical studies suggest that endogenous cholinergic …