The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …

In most cases, protein aggregation stems from the establishment of non-native
intermolecular contacts. The formation of insoluble protein aggregates is associated with …

Recombinant proteins play pivotal roles in numerous applications including industrial
biocatalysts or therapeutics. Despite the recent progress in computational protein structure …

Protein aggregation is behind the genesis of incurable diseases and imposes constraints on
drug discovery and the industrial production and formulation of proteins. Over the years, we …

Antimicrobial peptides (AMPs) are molecules widespread in all branches of the tree of life
that participate in host defense and/or microbial competition. Due to their positive charge …

Transition of soluble proteins into insoluble amyloid fibrils is driven by self-propagating short
sequence stretches. However, accurate prediction of aggregation determinants remains …

Neurodegenerative diseases (NDs) are characterized by abnormalities within neurons of the
brain or spinal cord that gradually lose function, eventually leading to cell death. Upon …

A long-standing goal of amyloid research has been to characterize the structural basis of the
rate-determining nucleating event. However, the ephemeral nature of nucleation has made …

Here we describe a surface-enhanced Raman scattering (SERS)-based
immunochromatographic assay (ICA) method for the dual detection of two pyrethroid …

Amyloid is an insoluble fibrous protein and its mis-aggregation can lead to some diseases,
such as Alzheimer's disease and Creutzfeldt–Jakob's disease. Therefore, the identification …