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Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9
The past decade has been one of rapid innovation in genome-editing technology. The
opportunity now exists for investigators to manipulate virtually any gene in a diverse range of …
opportunity now exists for investigators to manipulate virtually any gene in a diverse range of …
[HTML][HTML] Origins of programmable nucleases for genome engineering
S Chandrasegaran, D Carroll - Journal of molecular biology, 2016 - Elsevier
Genome engineering with programmable nucleases depends on cellular responses to a
targeted double-strand break (DSB). The first truly targetable reagents were the zinc finger …
targeted double-strand break (DSB). The first truly targetable reagents were the zinc finger …
Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing
X Kang, W He, Y Huang, Q Yu, Y Chen, X Gao… - Journal of assisted …, 2016 - Springer
Purpose As a powerful technology for genome engineering, the CRISPR/Cas system has
been successfully applied to modify the genomes of various species. The purpose of this …
been successfully applied to modify the genomes of various species. The purpose of this …
CRISPR-based functional genomics for neurological disease
Neurodegenerative, neurodevelopmental and neuropsychiatric disorders are among the
greatest public health challenges, as many lack disease-modifying treatments. A major …
greatest public health challenges, as many lack disease-modifying treatments. A major …
Applications of CRISPR–Cas systems in neuroscience
Genome-editing tools, and in particular those based on CRISPR–Cas (clustered regularly
interspaced short palindromic repeat (CRISPR)–CRISPR-associated protein) systems, are …
interspaced short palindromic repeat (CRISPR)–CRISPR-associated protein) systems, are …
Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2
Z Liu, X Li, JT Zhang, YJ Cai, TL Cheng, C Cheng… - Nature, 2016 - nature.com
Abstract Methyl-CpG binding protein 2 (MeCP2) has crucial roles in transcriptional
regulation and microRNA processing,,,. Mutations in the MECP2 gene are found in 90% of …
regulation and microRNA processing,,,. Mutations in the MECP2 gene are found in 90% of …
Streptococcus thermophilus CRISPR-Cas9 systems enable specific editing of the human genome
RNA-guided nucleases (RGNs) based on the type II CRISPR-Cas9 system of Streptococcus
pyogenes (Sp) have been widely used for genome editing in experimental models …
pyogenes (Sp) have been widely used for genome editing in experimental models …
Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
CRISPR/Cas9 has been used to genetically modify genomes in a variety of species,
including non-human primates. Unfortunately, this new technology does cause mosaic …
including non-human primates. Unfortunately, this new technology does cause mosaic …
[HTML][HTML] Brains, genes, and primates
One of the great strengths of the mouse model is the wide array of genetic tools that have
been developed. Striking examples include methods for directed modification of the …
been developed. Striking examples include methods for directed modification of the …
[HTML][HTML] Modeling Rett syndrome using TALEN-edited MECP2 mutant cynomolgus monkeys
Gene-editing technologies have made it feasible to create nonhuman primate models for
human genetic disorders. Here, we report detailed genotypes and phenotypes of TALEN …
human genetic disorders. Here, we report detailed genotypes and phenotypes of TALEN …