Dysfunction of the mesocorticolimbic dopaminergic reward system is a core feature of
schizophrenia (SZ), yet its precise contributions to different stages of reward processing and …

Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …

Pleasure is a fundamental driver of human behaviour, yet its neural basis remains largely
unknown. Rodent studies highlight opioidergic neural circuits connecting the nucleus …

Highlights•The Reward process and the Emotion process are intertwined.•Evaluative
appraisal processes determine the reward value of an event.•Different rewarding stimuli …

Social rewards are strong drivers of behavior and fundamental to well-being, yet there is a
lack of consensus regarding what actually defines a reward as “social.” Because a …

Studies conducted in rodents indicate a crucial role of the opioid circuit in mediating
objective hedonic reactions to primary rewards. However, it remains unclear whether opioid …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Apathy is a disabling syndrome associated with poor functional outcomes that is common
across a broad range of neurological and psychiatric conditions. Currently, there are no …

Abstract Purpose of Review Opioid receptors are widely expressed in the human brain. A
number of features commonly associated with drug use disorder, such as difficulties in …

The ventral striatum is implicated in the affective processing of reward, which can be divided
into a motivational and a hedonic component. Here, we examined whether these two …