Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an
increased possibility of adverse consequences such as falls, fractures, physical disabilities …

The aging population worldwide is facing a significant increase in age-related non-
communicable diseases, including cardiovascular and brain pathologies. This …

Sarcopenia is a severe loss of muscle mass and functional decline during aging that can
lead to reduced quality of life, limited patient independence, and increased risk of falls. The …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

With global population aging, age-related diseases, especially sarcopenia, have attracted
much attention in recent years. Characterized by low muscle strength, low muscle quantity or …

Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength,
and functions in elderly people. It is accompanied by physical frailty, functional disability …

Our previous studies support a key role for mitochondrial lipid hydroperoxides as important
contributors to denervation-related muscle atrophy, including muscle atrophy associated …

Sarcopenia, the age-related decline in muscle mass and function, derives from multiple
etiological mechanisms. Accumulative research suggests that reactive oxygen species …

Loss of innervation is a key driver of age associated muscle atrophy and weakness
(sarcopenia). Our laboratory has previously shown that denervation induced atrophy is …

Background Lipid hydroperoxides (LOOH) have been implicated in skeletal muscle atrophy
with age and disuse. Lysophosphatidylcholine acyltransferase 3 (LPCAT3), an enzyme of …