Simple Summary Numerous mechanisms of glioblastoma (GBM) radioresistance have been
identified but have not yet resulted in development of effective radiosensitizer that can …

Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …

Glioblastoma therapies have remained elusive due to limitations in understanding
mechanisms of growth and survival of the tumorigenic population. Using CRISPR-Cas9 …

Simple Summary Glioblastoma is one of the most treatment-refractory human malignancies,
and despite techniques that have allowed scientists and clinicians to better understand the …

In the decade following their initial discovery, the suppressor of cytokine signaling (SOCS)
proteins have been studied for their potential use as immunomodulators in disease. SOCS …

The epidermal growth factor receptor variant III (EGFRvIII) is associated with increased
proliferation of glioma cells. However, the impact of EGFRvIII on survival of patients with …

As a member of the suppressor of cytokine signaling (SOCS) family, SOCS3 is a cytokine-
inducible protein that inhibits cytokine signaling in a variety of signaling pathways …

Converging evidence indicates that the Fragile X Messenger Ribonucleoprotein (FMRP),
which absent or mutated in Fragile X Syndrome (FXS), plays a role in many types of cancers …

Glioma is the most common and malignant tumor of the central nervous system.
Glioblastoma (GBM) is the most aggressive glioma, with a poor prognosis and no effective …

Background Methylation of the O 6-methylguanine-DNA methyltransferase (MGMT) gene
promoter is a favorable prognostic factor in glioblastoma patients. However, reported …