The inflammasome NLRs in immunity, inflammation, and associated diseases
BK Davis, H Wen, JPY Ting - Annual review of immunology, 2011 - annualreviews.org
Inflammasome activation leads to caspase-1 activation, which causes the maturation and
secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup of the NLR …
secretion of pro-IL-1β and pro-IL-18 among other substrates. A subgroup of the NLR …
Inflammasomes and their roles in health and disease
Inflammasomes are a set of intracellular protein complexes that enable autocatalytic
activation of inflammatory caspases, which drive host and immune responses by releasing …
activation of inflammatory caspases, which drive host and immune responses by releasing …
IFI16 is an innate immune sensor for intracellular DNA
L Unterholzner, SE Keating, M Baran, KA Horan… - Nature …, 2010 - nature.com
The detection of intracellular microbial DNA is critical to appropriate innate immune
responses; however, knowledge of how such DNA is sensed is limited. Here we identify …
responses; however, knowledge of how such DNA is sensed is limited. Here we identify …
Regulation of inflammasome signaling
Innate immune responses have the ability to both combat infectious microbes and drive
pathological inflammation. Inflammasome complexes are a central component of these …
pathological inflammation. Inflammasome complexes are a central component of these …
[HTML][HTML] Exosome-inflammasome crosstalk and their roles in inflammatory responses
Inflammasome is a complex of multiple proteins found in cytoplasm of the cells activated by
infectious and/or non-infectious stimuli. This complex involves caspase-1 activation, leading …
infectious and/or non-infectious stimuli. This complex involves caspase-1 activation, leading …
Modulation of NF-κB signalling by microbial pathogens
MM Rahman, G McFadden - Nature Reviews Microbiology, 2011 - nature.com
The nuclear factor-κB (NF-κB) family of transcription factors plays a central part in the host
response to infection by microbial pathogens, by orchestrating the innate and acquired host …
response to infection by microbial pathogens, by orchestrating the innate and acquired host …
Battle royale: innate recognition of poxviruses and viral immune evasion
Host pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns
(PAMPs), which are molecular signatures shared by different pathogens. Recognition of …
(PAMPs), which are molecular signatures shared by different pathogens. Recognition of …
Molecular mechanisms of inflammasome activation during microbial infections
P Broz, DM Monack - Immunological reviews, 2011 - Wiley Online Library
The innate immune system plays a crucial role in the rapid recognition and elimination of
invading microbes. Detection of microbes relies on germ‐line encoded pattern recognition …
invading microbes. Detection of microbes relies on germ‐line encoded pattern recognition …
Poxviruses and the immune system: Implications for monkeypox virus
A Saghazadeh, N Rezaei - International Immunopharmacology, 2022 - Elsevier
Poxviruses (PXVs) are mostly known for the variola virus, being the cause of smallpox;
however, re-emerging PXVs have also shown a great capacity to develop outbreaks of pox …
however, re-emerging PXVs have also shown a great capacity to develop outbreaks of pox …
NOD-like receptors and the innate immune system: co** with danger, damage and death
Members of the family of NOD-like receptors (NLRs) play essential roles in innate immunity
by detecting intracellular 'pathogen-associated molecular patterns'(PAMPs) and 'danger …
by detecting intracellular 'pathogen-associated molecular patterns'(PAMPs) and 'danger …