DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of
Structure Prediction (CASP14) conference. We explored network architectures that …

Interactions between proteins and DNA play an important role in many essential biological
processes such as DNA replication, transcription, splicing, and repair. The identification of …

Thirty-eight percent of protein structures in the Protein Data Bank contain at least one metal
ion. However, not all these metal sites are biologically relevant. Cations present as …

The energy distribution along the protein–protein interface is not homogenous; certain
residues contribute more to the binding free energy, called 'hot spots'. Here, we present a …

Specific structures in mRNA modulate translation rate and thus can affect protein folding.
Using the protein structures from two eukaryotes and three prokaryotes, we explore the …

The factors that determine the conformation and stability of G-quadruplex forming
sequences remain poorly understood. Here we demonstrate the influence of cosolvents on …

All atom molecular dynamics simulations have become a standard method for map**
equilibrium protein dynamics and non-equilibrium events like folding and unfolding. Here …

The proteolysis of collagen triple-helical structure (collagenolysis) is a poorly understood yet
critical physiological process. Presently, matrix metalloproteinase 1 (MMP-1) and collagen …

Membrane fusion is essential to both cellular vesicle trafficking and infection by enveloped
viruses. While the fusion protein assemblies that catalyze fusion are readily identifiable, the …

A molecular description of protein− surface interactions could open new avenues in
bionanotechnology and provide a deeper understanding of in vivo phase boundary …