The pandemic caused by the coronavirus SARS-CoV-2 led to a global crisis in the world
healthcare system. Despite some progress in the creation of antiviral vaccines and mass …

The goal of cancer research is to identify characteristics of cancer cells that allow them to be
selectively eliminated without harming the host. One such characteristic is autophagy …

Abstract To date, Proteolysis Targeting Chimera (PROTAC) technology has been
successfully applied to mediate proteasomal-induced degradation of several …

Cathepsin L (CTSL), a cysteine cathepsin protease of the papain superfamily, plays a crucial
role in cancer progression and metastasis. Dysregulation of CTSL is frequently observed in …

The Pentamer complex of Human Cytomegalovirus (HCMV) consists of the viral
glycoproteins gH, gL, UL128, UL130, and UL131 and is incorporated into infectious virions …

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has triggered a protracted
global pandemic from 2019 to 2022, and posed a significant threat to human health. One of …

A large scale of pandemic coronavirus disease (COVID-19) in the past five years motivates a
great deal of endeavors donating to the exploration on therapeutic drugs against COVID-19 …

Background ADAM17 is a metalloprotease implicated in the proteolysis of angiotensin-
converting enzyme 2 (ACE2), known to play a critical role in the entry and spread of SARS …

Conjugation of organometallic entities to drug molecules is a strategy that often results in
products with new biological activity profiles compared to those of their progenitors. In this …

Coronavirus entry into host cells hinges on the interaction between the spike glycoprotein of
the virus and the cell-surface receptor angiotensin-converting enzyme 2 (ACE2), initiating …