Modeling mouse and human development using organoid cultures
In vitro three-dimensional (3D) cultures are emerging as novel systems with which to study
tissue development, organogenesis and stem cell behavior ex vivo. When grown in a 3D …
tissue development, organogenesis and stem cell behavior ex vivo. When grown in a 3D …
Orchestrating liver development
The liver is a central regulator of metabolism, and liver failure thus constitutes a major health
burden. Understanding how this complex organ develops during embryogenesis will yield …
burden. Understanding how this complex organ develops during embryogenesis will yield …
Pancreas organogenesis: from bud to plexus to gland
FC Pan, C Wright - Developmental dynamics, 2011 - Wiley Online Library
Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …
events and transcriptional networks that guide a step‐wise process of organ development …
Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations
Human pluripotent stem cell (hPSC) differentiation typically yields heterogeneous
populations. Knowledge of signals controlling embryonic lineage bifurcations could …
populations. Knowledge of signals controlling embryonic lineage bifurcations could …
[HTML][HTML] Organogenesis and development of the liver
Embryonic development of the liver has been studied intensely, yielding insights that impact
diverse areas of developmental and cell biology. Understanding the fundamental …
diverse areas of developmental and cell biology. Understanding the fundamental …
Unlimited in vitro expansion of adult bi‐potent pancreas progenitors through the Lgr5/R‐spondin axis
Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt‐agonistic R‐
spondins (RSPOs). Intestinal, stomach and liver Lgr5+ stem cells grow in 3D cultures to form …
spondins (RSPOs). Intestinal, stomach and liver Lgr5+ stem cells grow in 3D cultures to form …
Pancreas organogenesis: from lineage determination to morphogenesis
The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …
and exocrine function. In the past two decades, knowledge of how the pancreas develops …
Cellular and molecular mechanisms coordinating pancreas development
The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …
systemic glucose metabolism and food digestion through the function of its endocrine and …
Pluripotent stem cell-derived hepatocyte-like cells
Liver disease is an important clinical problem, impacting over 30 million Americans and over
600 million people worldwide. It is the 12th leading cause of death in the United States and …
600 million people worldwide. It is the 12th leading cause of death in the United States and …
Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm
Mesodermal signaling is critical for patterning the embryonic endoderm into different tissue
domains. Classical tissue transplant experiments in the chick and recent studies in the …
domains. Classical tissue transplant experiments in the chick and recent studies in the …