C-DNA may facilitate homologous DNA pairing

AK Mazur, E Gladyshev - Trends in Genetics, 2023 - cell.com
Recombination-independent homologous pairing represents a prominent yet largely
enigmatic feature of chromosome biology. As suggested by studies in the fungus …

Formation and resolution of meiotic chromosome entanglements and interlocks

I Olaya, SM Burgess, O Rog - Journal of cell science, 2024 - journals.biologists.com
Interactions between parental chromosomes during the formation of gametes can lead to
entanglements, entrapments and interlocks between unrelated chromosomes. If unresolved …

Active and thermal fluctuations in multi-scale polymer structure and dynamics

A Ghosh, AJ Spakowitz - Soft Matter, 2022 - pubs.rsc.org
The presence of athermal noise or biological fluctuations control and maintain crucial life-
processes. In this work, we present an exact analytical treatment of the dynamic behavior of …

[HTML][HTML] Viscoelastic active diffusion governed by nonequilibrium fractional Langevin equations: Underdamped dynamics and ergodicity breaking

S Joo, JH Jeon - Chaos, Solitons & Fractals, 2023 - Elsevier
In this work, we investigate the active dynamics and ergodicity breaking of a nonequilibrium
fractional Langevin equation (FLE) with a power-law memory kernel of the form K (t)∼ t−(2 …

Rapid meiotic prophase chromosome movements in Arabidopsis thaliana are linked to essential reorganization at the nuclear envelope

L Cromer, M Tiscareno-Andrade, S Lefranc… - Nature …, 2024 - nature.com
Meiotic rapid prophase chromosome movements (RPMs) require connections between the
chromosomes and the cytoskeleton, involving SUN (Sad1/UNC-84)-domain-containing …

Modeling homologous chromosome recognition via nonspecific interactions

WF Marshall, JC Fung - Proceedings of the National …, 2024 - National Acad Sciences
In many organisms, most notably Drosophila, homologous chromosomes associate in
somatic cells, a phenomenon known as somatic pairing, which takes place without double …

Agent-based modeling of nuclear chromosome ensembles identifies determinants of homolog pairing during meiosis

A Chriss, GV Börner, SD Ryan - PLOS Computational Biology, 2024 - journals.plos.org
During meiosis, pairing of homologous chromosomes (homologs) ensures the formation of
haploid gametes from diploid precursor cells, a prerequisite for sexual reproduction. Pairing …

Leveraging polymer modeling to reconstruct chromatin connectivity from live images

S Dutta, A Ghosh, AN Boettiger, AJ Spakowitz - Biophysical Journal, 2023 - cell.com
Chromosomal dynamics plays a central role in a number of critical biological processes,
such as transcriptional regulation, genetic recombination, and DNA replication. However …

Chromosome pairing through tensioned DNA tethers revealed by BRCA2 meiotic domain deletion

L Koornneef, SE van Rossum-Fikkert… - bioRxiv, 2023 - biorxiv.org
ABSTRACT BRCA2 has multiple functional domains that interact with different partners, and
is essential for both somatic and meiotic homologous recombination (HR). We created a …

Homologous chromosome recognition via nonspecific interactions

WF Marshall, JC Fung - bioRxiv, 2023 - biorxiv.org
In many organisms, most notably Drosophila, homologous chromosomes in somatic cells
associate with each other, a phenomenon known as somatic homolog pairing. Unlike in …