Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …

Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …

The development of immunotherapies over the past decade has resulted in a paradigm shift
in the treatment of cancer. However, the majority of patients do not benefit from …

Gemcitabine plus cisplatin (GP) chemotherapy is the standard of care for nasopharyngeal
carcinoma (NPC). However, the mechanisms underpinning its clinical activity are unclear …

The maintenance of organismal homeostasis requires partitioning and transport of
biochemical molecules between organ systems, their composite cells, and subcellular …

CD4+ T helper cells are key regulators of host health and disease. In the original model,
specialized subsets of T helper cells are generated following activation through lineage …

Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …

T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer.
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …