Aducanumab—hope or disappointment for Alzheimer's disease
K Wojtunik-Kulesza, M Rudkowska… - International journal of …, 2023 - mdpi.com
In June 2021, the world was informed about a new drug for Alzheimer's disease approved
by the FDA. Aducanumab (BIIB037, ADU), being a monoclonal antibody IgG1, is the newest …
by the FDA. Aducanumab (BIIB037, ADU), being a monoclonal antibody IgG1, is the newest …
Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines
D Puzzo, L Lee, A Palmeri, G Calabrese… - Biochemical …, 2014 - Elsevier
In Alzheimer's disease (AD) basic research and drug discovery, mouse models are essential
resources for uncovering biological mechanisms, validating molecular targets and screening …
resources for uncovering biological mechanisms, validating molecular targets and screening …
Amyloid–cholinesterase interactions: implications for Alzheimer's disease
Acetylcholinesterase is an enzyme associated with senile plaques. Biochemical studies
have indicated that acetylcholinesterase induces amyloid fibril formation by interaction …
have indicated that acetylcholinesterase induces amyloid fibril formation by interaction …
Acetylcholinesterase Inhibitors as Disease-Modifying Therapies for Alzheimer s Disease
DM Torrero - Frontiers in Medicinal Chemistry: Volume 7, 2015 - benthamdirect.com
The therapeutic arsenal for the treatment of Alzheimer s disease (AD) remains confined to a
group of four inhibitors of AChE and one NMDA receptor antagonist, which are used to …
group of four inhibitors of AChE and one NMDA receptor antagonist, which are used to …
Cholinesterases and the fine line between poison and remedy
Abstract Acetylcholinesterase (AChE, EC 3.1. 1.7) and butyrylcholinesterase (BChE, EC 3.1.
1.8) are related enzymes found across the animal kingdom. The critical role of …
1.8) are related enzymes found across the animal kingdom. The critical role of …
Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids …
I Bolea, J Juarez-Jimenez, C de los Rı́os… - Journal of medicinal …, 2011 - ACS Publications
A new family of multitarget molecules able to interact with acetylcholinesterase (AChE) and
butyrylcholinesterase (BuChE), as well as with monoamino oxidase (MAO) A and B, has …
butyrylcholinesterase (BuChE), as well as with monoamino oxidase (MAO) A and B, has …
Interactions of AChE with Aβ aggregates in Alzheimer's brain: therapeutic relevance of IDN 5706
FJ Carvajal, NC Inestrosa - Frontiers in molecular neuroscience, 2011 - frontiersin.org
Acetylcholinesterase (AChE; EC 3.1. 1.7) plays a crucial role in the rapid hydrolysis of the
neurotransmitter acetylcholine, in the central and peripheral nervous system and might also …
neurotransmitter acetylcholine, in the central and peripheral nervous system and might also …
The discovery of potential acetylcholinesterase inhibitors: a combination of pharmacophore modeling, virtual screening, and molecular docking studies
SH Lu, JW Wu, HL Liu, JH Zhao, KT Liu… - Journal of Biomedical …, 2011 - Springer
Background Alzheimer's disease (AD) is the most common cause of dementia characterized
by progressive cognitive impairment in the elderly people. The most dramatic abnormalities …
by progressive cognitive impairment in the elderly people. The most dramatic abnormalities …
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors
A Castro, A Martinez - Current pharmaceutical design, 2006 - ingentaconnect.com
Although the hallmarks of neurodegeneration in Alzheimer's brains are well known, one of
the current difficulties is related to the lack of solid evidence about the ultimate factors that …
the current difficulties is related to the lack of solid evidence about the ultimate factors that …
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's …
A series of 7-substituted coumarin derivatives were designed and synthesised to display
ChE and MAO-B inhibitory activity. The compounds consisted out of a coumarin structure …
ChE and MAO-B inhibitory activity. The compounds consisted out of a coumarin structure …