Local modulation by presynaptic receptors controls neuronal communication and behaviour

DM Lovinger, Y Mateo, KA Johnson, SA Engi… - Nature Reviews …, 2022 - nature.com
Central nervous system neurons communicate via fast synaptic transmission mediated by
ligand-gated ion channel (LGIC) receptors and slower neuromodulation mediated by G …

Biological functions of rat ultrasonic vocalizations, arousal mechanisms, and call initiation

SM Brudzynski - Brain Sciences, 2021 - mdpi.com
This review summarizes all reported and suspected functions of ultrasonic vocalizations in
infant and adult rats. The review leads to the conclusion that all types of ultrasonic …

D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning

JE Zachry, MG Kutlu, HJ Yoon, MZ Leonard, M Chevée… - Neuron, 2024 - cell.com
At the core of value-based learning is the nucleus accumbens (NAc). D1-and D2-receptor-
containing medium spiny neurons (MSNs) in the NAc core are hypothesized to have …

Ventral pallidal regulation of motivated behaviors and reinforcement

C Soares-Cunha, JA Heinsbroek - Frontiers in Neural Circuits, 2023 - frontiersin.org
The interconnected nuclei of the ventral basal ganglia have long been identified as key
regulators of motivated behavior, and dysfunction of this circuit is strongly implicated in …

Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1-and D2-medium spiny neurons

AV Domingues, TTA Carvalho, GJ Martins… - Nature …, 2025 - nature.com
The nucleus accumbens (NAc) is a key brain region for motivated behaviors, yet how distinct
neuronal populations encode appetitive or aversive stimuli remains undetermined. Using …

The nucleus accumbens in reward and aversion processing: insights and implications

Y Xu, Y Lin, M Yu, K Zhou - Frontiers in Behavioral Neuroscience, 2024 - frontiersin.org
The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been
implicated in a wide range of behaviors and emotional states. Emerging evidence, primarily …

Distinct role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior

C Soares-Cunha, AV Domingues, R Correia… - Cell Reports, 2022 - cell.com
The nucleus accumbens (NAc) is a key region in motivated behaviors. NAc medium spiny
neurons (MSNs) are divided into those expressing dopamine receptor D1 or D2. Classically …

Circulating triglycerides gate dopamine-associated behaviors through DRD2-expressing neurons

C Berland, E Montalban, E Perrin, M Di Miceli… - Cell metabolism, 2020 - cell.com
Energy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL)
system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yet the …

[HTML][HTML] Balance between projecting neuronal populations of the nucleus accumbens controls social behavior in mice

J Le Merrer, B Detraux, J Gandía, A De Groote… - Biological …, 2024 - Elsevier
Background Deficient social interactions are a hallmark of major neuropsychiatric disorders,
and accumulating evidence points to altered social reward and motivation as key underlying …

Cell-type-specific adaptions in striatal medium-sized spiny neurons and their roles in behavioral responses to drugs of abuse

MC Allichon, V Ortiz, P Pousinha… - Frontiers in synaptic …, 2021 - frontiersin.org
Drug addiction is defined as a compulsive pattern of drug-seeking-and taking-behavior, with
recurrent episodes of abstinence and relapse, and a loss of control despite negative …