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Do ionic liquids exhibit the required characteristics to dissolve, extract, stabilize, and purify proteins? Past-present-future assessment
Proteins are highly labile molecules, thus requiring the presence of appropriate solvents and
excipients in their liquid milieu to keep their stability and biological activity. In this field, ionic …
excipients in their liquid milieu to keep their stability and biological activity. In this field, ionic …
Lipid nanoparticle-mediated drug delivery to the brain
Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …
[HTML][HTML] Ionic liquids as protein stabilizers for biological and biomedical applications: A review
Biotechnology has revolutionized science and health care by providing new biomolecules
with biological and medical applications. However, the low stability of several life-saving …
with biological and medical applications. However, the low stability of several life-saving …
Use of ionic liquids in protein and DNA chemistry
SK Shukla, JP Mikkola - Frontiers in Chemistry, 2020 - frontiersin.org
Ionic liquids (ILs) have been receiving much attention as solvents in various areas of
biochemistry because of their various beneficial properties over the volatile solvents and ILs …
biochemistry because of their various beneficial properties over the volatile solvents and ILs …
Biocompatibility of ionic liquids towards protein stability: A comprehensive overview on the current understanding and their implications
Over the past years since the discovery of ionic liquids (ILs), there is an increased demand
to consider ILs as novel biocompatible co-solvents for proteins. Due to their tunable physical …
to consider ILs as novel biocompatible co-solvents for proteins. Due to their tunable physical …
[HTML][HTML] Probing HSA-ionic liquid interactions by spectroscopic and molecular docking methods
Herein, we report the interaction of synthesized pyrrolidinium based ionic liquid, N-butyl-N-
methyl-2-oxopyrrolidinium bromide (BMOP) with human serum albumin (HSA). The BMOP …
methyl-2-oxopyrrolidinium bromide (BMOP) with human serum albumin (HSA). The BMOP …
Biophysical insight into the binding mechanism of 1, 3-benzodioxole-based lidocaine tagged ionic liquids with BSA: an in-silico, and spectroscopic studies
The interaction between bio-macromolecules and drugs has attracted significant interest for
several decades due to their pharmacokinetics and pharmacological implications. Ionic …
several decades due to their pharmacokinetics and pharmacological implications. Ionic …
Protein aggregation and crystallization with ionic liquids: Insights into the influence of solvent properties
Ionic liquids (ILs) have been used in solvents for proteins in many applications, including
biotechnology, pharmaceutics, and medicine due to their tunable physicochemical and …
biotechnology, pharmaceutics, and medicine due to their tunable physicochemical and …
Insights into the interaction of Bovine Serum Albumin with Surface-Active Ionic Liquids in aqueous solution
The unique physicochemical properties of Ionic liquids (ILs) make them very desirable for
biomedical applications, namely as surface active ionic liquids (SAILs). SAILs surface …
biomedical applications, namely as surface active ionic liquids (SAILs). SAILs surface …
Biamphiphilic ionic liquid induced folding alterations in the structure of bovine serum albumin in aqueous medium
3-Methyl-1-octylimidazolium dodecylsulfate,[C8mim][C12OSO3], a vesicle forming
biamphiphilic ionic liquid (BAIL)(J. Phys. Chem. B 2012, 116, 14363–14374), has been …
biamphiphilic ionic liquid (BAIL)(J. Phys. Chem. B 2012, 116, 14363–14374), has been …