Inflammation drives coronary artery disease and atherosclerosis implications. Lipoprotein
entry, retention, and oxidative modification cause endothelial damage, triggering innate and …

Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown
etiology. It is characterized by the presence of rheumatoid factor and anti-citrullinated …

Our understanding of the role of T cells in human disease is undergoing revision as a result
of the discovery of T‐helper 17 (Th17) cells, a unique CD4+ T‐cell subset characterized by …

Ectopic lymphoid neogenesis often occurs in the target tissues of patients with chronic
rheumatic autoimmune diseases such as rheumatoid arthritis, Sjögren syndrome and other …

Fibroblast‐like synoviocytes (FLS) are resident mesenchymal cells of synovial joints that
have been recognized to play an increasingly important role in the pathogenesis of …

In the last years, mesenchymal stem cell (MSC)-based therapies have become an
interesting therapeutic opportunity for the treatment of rheumatoid arthritis (RA) due to their …

T cells are adaptive immune cells essential in pathogenic response, cancer, and
autoimmune disorders. During the integration of biomaterials with host tissue, T cells modify …

IL-17 is the defining cytokine of a newly-described “Th17” population that plays critical roles
in mediating inflammation and autoimmunity. The IL-17/IL-17 receptor superfamily is the …

Abstract The activator protein-1 (AP-1) family of transcription factors modulate a diverse
range of cellular signalling pathways into outputs which can be oncogenic or anti …

Objective To examine the regulatory role of interleukin‐22 (IL‐22) in the expression of
RANKL and induction of osteoclastogenesis in rheumatoid arthritis (RA). Methods …