Antibody therapies have become an important class of therapeutics in recent years as they
have exhibited outstanding efficacy and safety in the treatment of several major diseases …

Simple Summary Ovarian cancer is a lethal gynecologic tumor and is generally resistant to
conventional treatments. Stable cancer-associated fibroblasts (CAFs) are important cellular …

The cancer burden continues to grow globally, and drug resistance remains a substantial
challenge in cancer therapy. It is well established that cancerous cells with clonal dysplasia …

Abstract Interleukin-6 (IL-6), a pro-inflammatory cytokine, plays a crucial role in host immune
defense and acute stress responses. Moreover, it modulates various cellular processes …

Abstract Interleukin 6 (IL-6) is a pleiotropic cytokine that is strongly implicated in the
development and progression of ovarian cancer. The most recognized actions of IL-6 in …

Ovarian cancer, one of the deadliest malignancies, lacks effective treatment, despite
advancements in surgical techniques and chemotherapy. Thus, new therapeutic …

Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a
poor prognosis and limited treatment options. Recent work identifying high concentrations of …

Colorectal cancer (CRC) is one of the most common cancers globally. Although a variety of
CRC screening methods have been developed, many patients are diagnosed at advanced …

Ovarian cancer is the most lethal gynecological cancer type in the United States. The
success of current chemotherapies is limited by chemoresistance and side effects. Targeted …

The inflammatory milieu in tumor modulates the resistance to the conventional antitumoral
therapies. Interleukin-6 (IL-6), a pleiotropic pro-inflammatory cytokine and a crucial mediator …