Vitamin B 12, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that
represents one of the most complex small molecules made by nature. In prokaryotes it is …

Almost half of all enzymes must associate with a particular metal to function. An ambition is
to understand why each metal–protein partnership arose and how it is maintained. Metal …

Lag phase represents the earliest and most poorly understood stage of the bacterial growth
cycle. We developed a reproducible experimental system and conducted functional genomic …

Protein metal-coordination sites are richly varied and exquisitely attuned to their inorganic
partners, yet many metalloproteins still select the wrong metals when presented with …

Biology capitalizes on the specific chemistries of certain transition metal ions. In fact, life
depends on transition metal ions as essential trace elements. Biological redox processes …

The transition or d-block metal ions manganese, iron, cobalt, nickel, copper, zinc and to a
more specialized degree molybdenum, tungsten, and vanadium have been shown to be …

Among the biologically required first row, late d-block metals from Mn II to Zn II, the catalytic
and structural reach of Zn II ensures that this essential micronutrient touches nearly every …

There is a challenge for metalloenzymes to acquire their correct metals because some
inorganic elements form more stable complexes with proteins than do others. These …

Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

Bacteria regularly encounter widely varying metal concentrations in their surrounding
environment. As metals become depleted or, conversely, accrue to toxicity, microbes will …