Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …

Dorsal root ganglion (DRG) neurons are the first neurons of the sensory pathway. They are
activated by a variety of sensory stimuli that are then transmitted to the central nervous …

Background Chronic pain is often accompanied by short-term memory deficit and
depression. Currently, it is believed that short-term memory deficit and depression are …

Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

Chronic pain continues to be a significant global burden despite the availability of a variety
of nonpharmacologic and pharmacologic treatment options. Thus, there is a need for new …

Sensory abnormalities generated by nerve injury, peripheral neuropathy or disease are
often expressed as neuropathic pain. This type of pain is frequently resistant to therapeutic …

Regeneration of injured nerve tissues requires intricate interplay of complex processes like
axon elongation, remyelination, and synaptic formation in a tissue‐specific manner. A …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Background Clinically, it is well known that injury of mandibular nerve fiber induces
persistent ectopic pain which can spread to a wide area of the orofacial region innervated by …

Musculoskeletal pain such as osteoarthritis (OA) and low back pain (LBP) are very common
and contribute to enormous burden and societal costs, despite dramatic therapeutic …