Prepulse inhibition (PPI) is a robust operational measure of sensorimotor gating. In
schizophrenic patients PPI is deficient. The aim of our review was to investigate the state of …

Endogenous adenosine is a widely distributed upstream regulator of a broad spectrum of
neurotransmitters, receptors, and signaling pathways that converge to contribute to the …

Perceptual abnormalities such as hyperacusis and tinnitus often occur after acoustic
overexposure. Although such exposure can also result in permanent threshold elevation …

The startle response is composed by a set of reflex behaviors intended to prepare the
organism to face a potentially relevant stimulus. This response can be modulated by several …

Abstract The serotonin-2A receptor (5-HT 2A R) has been implicated in the pathogenesis of
schizophrenia and related inhibitory gating and behavioral inhibition deficits of …

Background No animal models of autism spectrum disorders (ASD) with good construct
validity are currently available; using genetic models of pathologies characterized by ASD …

Sensory processing, and auditory processing in particular, is altered in individuals with
neurodevelopmental disorders such as autism spectrum disorders (ASDs). The typical …

Abstract The 22q11. 2 deletion syndrome (22q11. 2DS) is associated with an increased risk
for psychiatric disorders. Although most of the 22q11. 2DS patients have a 3.0-Mb deletion …

Dopamine dysregulation contributes to psychosis and cognitive deficits in schizophrenia that
can be modelled in rodents by inducing maternal immune activation (MIA). The selective …

The phantom perception of tinnitus and reduced sound-level tolerance associated with
hyperacusis have a high comorbidity and can be debilitating conditions for which there are …