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Targeting Tau hyperphosphorylation via kinase inhibition: strategy to address Alzheimer's disease
Microtubule-associated protein tau is involved in the tubulin binding leading to microtubule
stabilization in neuronal cells which is essential for stabilization of neuron cytoskeleton. The …
stabilization in neuronal cells which is essential for stabilization of neuron cytoskeleton. The …
Virtual screening approach to identify high-affinity inhibitors of serum and glucocorticoid-regulated kinase 1 among bioactive natural products: Combined molecular …
Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase that works
under acute transcriptional control by several stimuli, including serum and glucocorticoids. It …
under acute transcriptional control by several stimuli, including serum and glucocorticoids. It …
[HTML][HTML] Ellagic acid controls cell proliferation and induces apoptosis in breast cancer cells via inhibition of cyclin-dependent kinase 6
Cyclin-Dependent Kinase 6 (CDK6) plays an important role in cancer progression, and thus,
it is considered as an attractive drug target in anticancer therapeutics. This study presents an …
it is considered as an attractive drug target in anticancer therapeutics. This study presents an …
Identification and evaluation of bioactive natural products as potential inhibitors of human microtubule affinity-regulating kinase 4 (MARK4)
Microtubule affinity-regulating kinase 4 (MARK4) has recently been identified as a potential
drug target for several complex diseases including cancer, diabetes and neurodegenerative …
drug target for several complex diseases including cancer, diabetes and neurodegenerative …
Investigation of molecular mechanism of recognition between citral and MARK4: A newer therapeutic approach to attenuate cancer cell progression
Microtubule affinity regulating kinase 4 (MARK4) is a member of AMP-activated protein
kinase, found to be involved in apoptosis, inflammation and many other regulatory …
kinase, found to be involved in apoptosis, inflammation and many other regulatory …
Elucidation of dietary polyphenolics as potential inhibitor of microtubule affinity regulating kinase 4: in silico and in vitro studies
Microtubule affinity regulating kinase 4 (MARK4) is a Ser/Thr kinase belonging to AMPK-like
family, has recently become an important drug target against cancer and neurodegenerative …
family, has recently become an important drug target against cancer and neurodegenerative …
Identification of sphingosine kinase-1 inhibitors from bioactive natural products targeting cancer therapy
Sphingosine kinase 1 (SphK1) is an oncogenic lipid kinase that catalyzes the formation of
sphingosine-1-phosphate via phosphorylation of sphingosine and known to play a crucial …
sphingosine-1-phosphate via phosphorylation of sphingosine and known to play a crucial …
Identification of potential inhibitors of calcium/calmodulin‐dependent protein kinase IV from bioactive phytoconstituents
Calcium/calmodulin‐dependent protein kinase IV (CaMKIV) is an upstream regulator of
CaMKK‐CaMKIV signaling cascade that activates various transcription factors, thereby …
CaMKK‐CaMKIV signaling cascade that activates various transcription factors, thereby …
Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells
Human calcium/calmodulin-dependent protein kinase IV (CAMKIV) is a member of Ser/Thr
kinase family, and is associated with different types of cancer and neurodegenerative …
kinase family, and is associated with different types of cancer and neurodegenerative …
High throughput screening, docking, and molecular dynamics studies to identify potential inhibitors of human calcium/calmodulin-dependent protein kinase IV
Calcium/calmodulin-dependent protein kinase IV (CAMKIV) is associated with many
diseases including cancer and neurodegenerative disorders and thus being considered as …
diseases including cancer and neurodegenerative disorders and thus being considered as …