Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

Publisher Summary This chapter discusses the use of inhibitors of tyrosyl-DNA
phosphodiesterase (Tdp1) and Chk1/2 in combination with Topoisomerase I (TopI) …

Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is formed by conversion
of capsid-associated relaxed circular DNA (rcDNA) via unknown mechanisms and exists in …

During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs topoisomerase I cleavage complexes
(Top1cc) by hydrolyzing their 3′-phosphotyrosyl DNA bonds and repairs bleomycin …

Anticancer topoisomerase “poisons” exploit the break-and-rejoining mechanism of
topoisomerase II (TOP2) to generate TOP2-linked DNA double-strand breaks (DSBs). This …

Human tyrosyl-DNA phosphodiesterase (Tdp1) hydrolyzes the phosphodiester bond
between a DNA 3′ end and a tyrosyl moiety. In eukaryotic cells, this type of linkage is found …

Background Although early-stage non-small-cell lung cancer (NSCLC) is considered a
potentially curable disease following complete resection, patients have a wide spectrum of …

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an important repair enzyme that removes
various covalent adducts from the 3′ end of DNA. Particularly, covalent complexes of …

Tyrosyl‐DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of the tyrosyl‐3′
phosphate linkage found in topoisomerase I–DNA covalent complexes. The inherited …